Thyroid hormone plays an essential role in myogenesis, the process required for skeletal muscle development and repair, although the mechanisms have not been established. Skeletal muscle develops from the fusion of precursor myoblasts into myofibers. We have used the C2C12 skeletal muscle myoblast cell line, primary myoblasts, and mouse models of resistance to thyroid hormone (RTH) α and β, to ...

In this paper we consider a generalization of the p-center problem called the r-all-neighbor p-center problem (RANPCP). The objective of the RANPCP is to minimize the maximum distance from a demand point to its rth-closest located facility. The RANPCP is applicable to facility location with disruptions because it considers the maximum transportation distance after (r − 1) facilities are disrupt...

OBJECTIVE The aim of the study was to describe the clinical, biochemical, and genetic features of a sample of Mediterranean patients with RTH (resistance to thyroid hormone) due to mutations in TRβ (thyroid hormone receptor beta) referred to our institution during the last 15 years. DESIGN 166 blood samples were received for RTH genetic testing between January 1997 and December 2011. Genetic ...

We report the clinical and laboratory findings, and molecular analysis of a Brazilian patient with resistance to thyroid hormone syndrome (RTH) detected by neonatal screening. The index case was born at term by normal delivery with 2,920 g and 45 cm. TSH of the neonatal screening test performed on the 5(th) day of life was of 13.1 µU/mL (cut-off = 10 µU/mL). In a confirmatory test, serum TSH le...

A partial differential Progressive Tubular Reabsorption (PTR) model, describing renal tubular glucose reabsorption and urinary glucose excretion following a glucose load perturbation, is proposed and fitted to experimental data from five subjects. For each subject the Glomerular Filtration Rate was estimated and both blood and urine glucose were sampled following an Intra-Venous glucose bolus. ...

Steroid receptor co-activator 1 (SRC-1) is a transcription co-factor that enhances the hormone-dependent action, mediated by the thyroid hormone (TH) receptor (TR) and other nuclear receptors. In vitro studies have shown that SRC-1 is necessary for the full expression of TH effect. SRC-1 knockout mice (SRC-1(-/-)) provide a model to examine the role of this co-activator on TH action in vivo. At...

Resistance to thyroid hormone (RTH) is a rare autosomal dominant inherited disorder characterized by end-organ reduced sensitivity to thyroid hormone. This syndrome is caused by mutations of the thyroid hormone receptor (TR) β gene, and its clinical presentation is quite variable. Goiter is reported to be the most common finding. A close association of TRβ mutations with human cancers has becom...

A new method of parameter identification based on linear time-frequency representation and Hilbert transform is proposed in this paper to identify modal parameters of linear time-varying systems from measured vibration responses. With Gabor expansion and synthesis theory, measured responses are represented in time-frequency domain and modal components are reconstructed by time-frequency filteri...

I t is shown t h a t in the r t h order binary Reed-Muller code of length N = 2" and m i n i m u m distance d = 2~-L the only code-words having weight between d and 2d are those with weights of the form 2d-2 t for some i. The same result also holds for certain super-codes of the R M codes. DEFI~ITm~<. T h e weight of an integer k, W(/~), is the n u m b e r of l's in the binary expansion of ]~. ...