Receptor tyrosine kinases (RTK) or ligands have frequent genetic alterations in cancers. Either amplifications, missense mutations fusions of RTK are biomarkers for some targeted therapies a fraction cancers, with heterogeneous responses to kinase inhibitors (TKI), monoclonal antibodies (mabs) andibody-drug conjugates (ADC). An analysis pan-cancer molecular and clinical outcome RTK-altered canc...

Abstract. PPP-RTK has been widely investigated to take the advantages of both real-time kinematic (RTK) and precise point positioning (PPP) techniques. Prior PPP-RTK, conventional RTK based on use a single base station, one hand, extended work within regional network multiple stations, known as (NRTK). The NRTK enable fast ambiguity resolution over short baseline or local region. PPP, other eli...

The receptor tyrosine kinase (RTK) signaling pathway is used reiteratively during the development of all multicellular organisms. While the core RTK/Ras/MAPK signaling cassette has been studied extensively, little is known about the nature of the downstream targets of the pathway or how these effectors regulate the specificity of cellular responses. Drosophila yan is one of a few downstream com...

Dual-frequency Global Positioning System (GPS) Real-time Kinematics (RTK) has been proven in the past few years to be a reliable and efficient technique to obtain high accuracy positioning. However, there are still challenges for GPS single-frequency RTK, such as low reliability and ambiguity resolution (AR) success rate, especially in kinematic environments. Recently, multi-Global Navigation S...

2019. augusztus 1-jétőlképviselem a Belügyminisztériumot (BM) Nemzeti Közszolgálati Egyetem Tanácsadó Testületében (NKE TT). Ebben beosztásban tolmácsolom belügyi vezetés szakmai elvárásait az NKE és Rendészettudományi Karának (RTK) vezetői, tanárai diákjai felé. Ez munka természetesen különböző formában intenzitással folyt korábban is, Rendőrtiszti Főiskola működése idején RTK megalakulása utá...

Kinase inhibitors have limited success in cancer treatment because tumors circumvent their action. Using a quantitative proteomics approach, we assessed kinome activity in response to MEK inhibition in triple-negative breast cancer (TNBC) cells and genetically engineered mice (GEMMs). MEK inhibition caused acute ERK activity loss, resulting in rapid c-Myc degradation that induced expression and...

The coming decade will bring a proliferation of Global Navigation Satellite Systems (GNSSs) that are likely to enable a much wider range of demanding applications compared to the current GPS-only situation. One such important area of application is single-frequency real-time kinematic (RTK) positioning. Presently, however, such systems lack real-time performance. In this contribution we analyze...

Since the advent of Geographic Information Systems (GIS) people specialised in this area or connected with GIS at an administrative or user level have been looking for economical and productive means to accomplish data acquisition tasks. Because the data acquisition constitutes a major part of any GIS, the scientific community, especially geodetic surveyors, have come up with the real time kine...

Activation of distinct receptor tyrosine kinases (RTK), such as the products of the c-fms and c-kit proto-oncogenes, profoundly affects hematopoietic development. We have isolated a novel RTK cDNA, called met-related kinase (MRK), which is expressed on early erythroid progenitors. MRK is also expressed in many hematopoietic cell lines, and is not lineage restricted. Several regions within the c...