Let X be a closed smooth 4-manifold. In the Theory of the SeibergWitten Equations, the configuration space is Cα = Aα × Γ (S + α ), where Aα is a space of u1-connections defined on a complex line bundle over X and Γ (S α ) is the space of sections of the positive complex spinor bundle over X. The original SWα-equations are 1 -order PDE fitting into a variational principle SWα : Aα × Sα → R, whi...

1 The aims of the present study were to characterize the cyclic nucleotide phosphodiesterase (PDE) isoenzyme activities present in human bronchi and to examine the ability of selective isoenzyme inhibitors to relax histamine and methacholine precontracted preparations of human bronchi. 2 Three separations of pooled human bronchial tissue samples were performed. Ion-exchange chromatography showe...

The effect of selective PDE-I (vinpocetine), PDE-III (milrinone, CI-930), PDE-IV (rolipram, nitroquazone), and PDE-V (zaprinast) isozyme inhibitors on TNF-alpha and IL-1beta production from LPS stimulated human monocytes was investigated. The PDE-IV inhibitors caused a concentration dependent inhibition of TNF-alpha production, but only partially inhibited IL-1beta at high concentrations. High ...

This paper develops an adaptive PDE observer for battery state-of-charge (SOC) and state-of-health (SOH) estimation. Realtime state and parameter information enables operation near physical limits without compromising durability, thereby unlocking the full potential of battery energy storage. SOC/SOH estimation is technically challenging because battery dynamics are governed by electrochemical ...

This article addresses the stabilization of nonlinear reaction–diffusion equation with an unknown but bounded delay. Based on Takagi–Sugeno (T–S) fuzzy rules, a T–S partial differential (PDE) model is constructed to describe distributed parameter system. More importantly, we contribute large delay compensation and future state prediction by introducing chain subpredictors for PDE model, converg...

Efficient and productive virus infection often requires viral countermeasures that block innate immunity. The IFN-inducible 2',5'-oligoadenylate (2-5A) synthetases (OASs) and ribonuclease (RNase) L are components of a potent host antiviral pathway. We previously showed that murine coronavirus (MHV) accessory protein ns2, a 2H phosphoesterase superfamily member, is a phosphodiesterase (PDE) that...

A compact sized PDE with an i.d. of 0.75 in. and length of 1 m was paired with an automotive turbocharger. The turbine-compressor shaft was used to drive a small ac generator by means of speed reduction wheels. The PDE was tested with propane-oxygen mixture at 15 Hz for a period of about 20 s. The turbine spun up to a speed of 127,000 rpm, whilst the generator produced electric power at 27 W an...

The level of phosphodiesterase (PDE) activity is lower in collagenase-isolated human fat cells than in adipose tissue fragments. The inhibition is not species-specific since collagenase also inhibits PDE in rat adipose tissue and bovine heart. In subcellular fractions from isolated fat cells, the PDE activities were lowest in the plasma membrane-enriched fractions and highest in the cytosolic f...

Trypanosoma cruzi phosphodiesterase C (TcrPDEC) is a potential new drug target for the treatment of Chagas disease but has not been well studied. This study reports the enzymatic properties of various kinetoplastid PDECs and the crystal structures of the unliganded TcrPDEC1 catalytic domain and its complex with an inhibitor. Mutations of PDEC during the course of evolution led to inactivation o...