Phosphorylation of S17 in the N-terminal "lid" of MDM2 (residues 1-24) is proposed to regulate the binding of p53. The lid is composed of an intrinsically disordered peptide motif that is not resolved in the crystal structure of the MDM2 N-terminal domain. Molecular dynamics simulations of MDM2 provide novel insight into how the lid undergoes complex dynamics depending on its phosphorylation st...

6 DFT Results S11 Figure S6. Computed molecules . . . . . . . . . . . . . . . . . . . . . . . . . . . . S11 6.1 {[PC(sp)P]PdI}2 ({2}2) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S12 Table S1. Optimized coordinates for {[PC(sp)P]PdI}2 ({2}2) . . . . . . . . . . . . . S12 Figure S7. Overlaid structures for {[PC(sp)P]PdI}2 ({2}2) (red: X-ray, blue: optimized) . . . . . . . . ....

Amid rigid competition in marketing to accomplish customers' needs, the cost of disappointment is too high. In an effort to escape market disappointment, one of the options to be considered is probing for customer satisfaction through sensory evaluation. This study aims to rank the six selected milk-barberry drink formulae out of 24 (code numbers S3, S4, S15, S16, S17 and S18) each having diffe...

Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S1 Section 1 Multidisciplinary care . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

Recently, the solar fusion reaction Be(p,γ)B has received renewed interest: on one hand, it represents the source of the high-energy neutrinos that have been measured in the SNO and Super-Kamiokande experiments to pin down neutrino oscillations; the zero-energy S17-factor is directly proportional to the predicted solar neutrino flux to be compared to the SNO and Super-K experiments. On the othe...