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In 1881 British ophthalmologist Warren Tay made an unusual observation. He reported a cherry-red spot on the retina of a one-year-old patient, a patient who was also showing signs of progressive degeneration of the central nervous system [4] as manifested in the child?s physical and mental retardation [5]. This cherry-red spot is a characteristic that would eventually come to be associated with...

We present a pedagogical derivation of the SachsWolfe effect, specifically the factor 3 relating the temperature fluctuations to gravitational potentials. The result arises from a cancellation between gravitational redshifts and intrinsic temperature fluctuations which can be derived from a coordinate transformation of the background.

Hexosaminidase A is present in relatively low concentrations in cell-free amniotic fluids from pregnancies with Tay-Sachs fetuses. This isoenzyme was determined by an immunological procedure, radial immunodiffusion, by which hexosaminidase A can be directly and specifically detected, even in the presence of excess amounts of hexosaminidase B. No hexosaminidase A could be detected by the same pr...

Fine twinned microstructures with {225}γ habit planes are commonly observed in martensitic steels. The present study shows that an equibalanced combination of twin-related variants associated to the Kurdjumov-Sachs orientation relationship is equivalent to the Bowles and Mackenzie's version of the PTMC for this specific {225}γ case. The distortion associated to the Kurdjumov-Sachs orientation r...

The metabolism of Tay-Sachs ganglioside, Cer-Glc-Gal(NeuAc)-GalNAc (G& was investigated by using GNIZ specifically labeled with 3H in the NeuAc moiety or with W in GalNAc. There are two possible pathways for the catabolism of GM2 in brain, initiated via GMM-sialidase or GM2hexosaminidase. The products of the sialidase reaction were identified and are Cer-Glc-Gal-GalNAc and NeuAc; the hexosamini...

Together with water and carbon dioxide plants require 14 essential mineral nutrients to finish their life cycle. The research in plant nutrition can be traced back to Julius Sachs, who was the first to experimentally prove the essentiality of mineral nutrients for plants. Among those elements Sachs showed to be essential is sulfur. Plant sulfur nutrition has been not as extensively studied as t...