Extrinsic cues activate intrinsic signaling mechanisms to pattern neuronal shape and connectivity. We showed previously that three cytoplasmic Ser/Thr kinases, LKB1, SAD-A, and SAD-B, control early axon-dendrite polarization in forebrain neurons. Here, we assess their role in other neuronal types. We found that all three kinases are dispensable for axon formation outside of the cortex but that ...

Artworks with sad and affectively negative content have repeatedly been reported to elicit positive aesthetic appreciation. This topic has received much attention both in the history of poetics and aesthetics as well as in recent studies on sad films and sad music. However, poetry and aesthetic evaluations of joyful and sad poetry have received only little attention in empirical studies to date...

Systems analysis and design (SAD) is a core part of systems development and the Information Systems curriculum (Gorgone et al, 2002; Bajaj et al, 2004). SAD is a complex process, with many techniques used to understand problems and design solutions. This paper investigates how an agile software development approach may be used for the teaching and learning of SAD. The research reviews and compa...

Exaggerated anticipatory anxiety during expectation of performance-related situations is an important feature of the psychopathology of social anxiety disorder (SAD). The neural basis of anticipatory anxiety in SAD has not been investigated in controlled studies. The current study used functional magnetic resonance imaging (fMRI) to investigate the neural correlates during the anticipation of p...

Music emotion recognition and recommendation systems often use a simplified 4-quadrant model with categories such as Happy, Sad, Angry, and Calm. Previous research has shown that both listeners and automated systems often have difficulty distinguishing low-arousal categories such as Calm and Sad. This paper seeks to explore what makes the categories Calm and Sad so difficult to distinguish. We ...

BACKGROUND The sagittal abdominal diameter (SAD) measured in supine position is an alternative adiposity indicator that estimates the quantity of dysfunctional adipose tissue in the visceral depot. However, supine SAD's distribution and its association with health risk at the population level are unknown. Here we describe standardized measurements of SAD, provide the first, national estimates o...

BACKGROUNDS AND AIMS Visceral fat has a crucial role in the development and progression of cardiovascular disease, the major cause of death in end-stage renal disease (ESRD). Although sagittal abdominal diameter (SAD), as an index of visceral fat, significantly correlated with mortality in the general population, the impact of SAD on clinical outcomes has never been explored in ESRD patients. T...

Implicit associations of the self to concepts like "calm" have been shown to be weaker in persons with social anxiety than in non-anxious healthy controls. However, other implicit self associations, such as those to acceptance or rejection, have been less studied in social anxiety, and none of this work has been conducted with clinical samples. Furthermore, the importance of depression in these...

BACKGROUND Child maltreatment is associated with heightened risk for depression; however, not all individuals who experience maltreatment develop depression. Previous research indicates that maltreatment contributes to an attention bias for emotional cues, and that depressed individuals show attention bias for sad cues. METHOD The present study examined attention patterns for sad, depression-...

This paper describes the design of a high speed motion estimator using the Z-D log search algorithm. The architecture consists of 5 simple processing elements (PE) where each PE is capable of computing the sum-of-absolute-difference (SAD) to exploit the parallelism. For each step in the 2-D log search procedure, the 5 SADs of the 5 search points are computed in parallel. The design is implement...