Surrogate end points in clinical research pose real danger. A surrogate end point is an outcome measure, commonly a laboratory test, that substitutes for a clinical event of true importance. Resistance to activated protein C, for example, has been used as a surrogate for venous thrombosis in women using oral contraceptives. Other examples of inappropriate surrogate end points in contraception i...

Background Misconceptions about medications' safety can lead pregnant women with asthma to stop their medications, resulting in asthma-related neonatal morbidity and mortality. Our aim was to assess the level of pregnancy-related asthma knowledge and education about asthma medications' safety, among women of childbearing age with a history of bronchial asthma. Methods A cross-sectional survey...

Nowadays laser is extensively used in various industrial, communicative, medical, and other fields. Using laser in medicine has enabled physicians to perform the most accurate and finest operations within few minutes. Non-observance of safety points during laser performance could be seriously harmful for the medical staff and the patient. Therefore, in order to prevent the possible damage of th...

The management of breast cancer during pregnancy poses unique challenges and requires a multi-disciplinary approach. In this review, we discuss the treatment of breast cancer in pregnancy and recent updates regarding the safety of surgical and chemotherapeutic treatments, including both oncologic and fetal outcomes. The treatment of breast cancer during pregnancy mirrors that outside of pregnan...

BACKGROUND Regulatory agencies often request prospective, product-specific post-authorization pregnancy exposure registries to monitor safety during pregnancy, even though studies using existing health databases could also be employed. OBJECTIVES Using multiple sclerosis (MS) as a case study, we evaluated various study designs and data sources previously used to study medication exposure in p...