Invasive micropapillary carcinoma (IMPC) is defined as a carcinoma composed of small clusters of tumor cells lying within clear spaces which simulate lymphovascular channels. This histologic pattern has been described in various organs, including the breast, lung, urinary bladder, ovary, stomach, pancreas, and major salivary glands. Although rarely observed as a pure histologic component, IMPC ...

OBJECTIVE Our study aimed to characterize alteration in the immunohistochemical expression of p21 in normal tissue of the salivary gland surrounding pleomorphic adenoma, the tumor cells of pleomorphic adenomas, and carcinoma arising in pleomorphic adenoma. STUDY DESIGN A selected series of 29 cases of pleomorphic adenomas, and 27 cases of carcinoma ex-pleomorphic adenoma (undifferentiated and...

INTRODUCTION Carcinoma ex pleomorphic adenoma (CXPA) of the salivary glands has often a salivary duct carcinoma (SDC) component, which resembles ductal carcinoma of the breast and frequently overexpresses human epidermal growth factor receptor-2 (HER2). We report a case of metastatic CXPA with SDC component who was treated with trastuzumab-based chemotherapy and has had a durable complete respo...

abstract background: thyroglossal duct cysts (tdc) are the most common congenital neck masses arising from the expansion of the epithelial tract remnants occurring during embryogenic thyroid migration. about 7% of the population have thyroglossal duct remnants. clinical presentation is frequent in children, but adults can also present with thyroglossal duct cysts. thyroglossal duct cysts may ra...

thyroglossal duct cysts are the most common form of congenital cysts on the neck. the incidence of thyroid papillary carcinoma in thyroglossal duct cyst is less than 1%. in most cases the diagnosis is made postoperatively. we present a 22-year-old female with thyroid papillary carcinoma arising from thyroglossal duct cyst,identified in pathologic study after sistrunk operation.in our case there...