INTRODUCTION Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) is an acronym for various osteoarticular and dermatological manifestations that can appear in the same patient. It is a rare syndrome, but since its awareness has increased, there have been more and more such reports in the literature. AIMS The objectives of this review are to summarize the current state of knowledge on pedi...

Background Chronic non-bacterial osteomyelitis (CNO) is a rare bone disease occurring in children and adults. Adults mainly present with osteitis hyperostosis of the anterior chest wall, sometimes context synovitis, acne, pustulosis, hyperostosis, (SAPHO) syndrome [1]. CNO hypothesized to be an auto-inflammatory disease, as studies on pediatric patients have shown raised erythrocyte sedimentati...