INTRODUCTION The acronym SAPHO was introduced in 1987 to unify the various descriptions of a seronegative arthritis associated with skin manifestations and to show synovitis, acne, pustulosis, hyperostosis, and osteitis with and without sterile multifocal osteomyelitis. The etiology of SAPHO syndrome is unknown, but an association with infection by semipathogenic bacteria like Propionibacterium...

We report the case of a 50-year-old Japanese woman with SAPHO (synovitis-acne-pustulosis-hyperostosisosteomyelitis) syndrome. Radiographs showed osteosclerosis of the cervical and lumbar vertebrae, as well as osteosclerosis and osteolysis of the right femoral neck, resembling multiple metastatic bony lesions. Arriving at a diagnosis required hematological and imaging tests. Whole-body bone scin...

INTRODUCTION Angiogenesis is involved in the pathogenesis of arthritis. OBJECTIVES The aim of the study was to assess the serum levels of selected angiogenic cytokines and their association with clinical presentation in patients with psoriatic arthritis (PsA) and SAPHO syndrome. PATIENTS AND METHODS We studied 98 patients: 80 with PsA and 18 with SAPHO syndrome. The following data were reco...

Introduction SAPHO syndrome is defined as the association of a group of rare sterile osteoarticular disorders and inflammatory skin diseases whose etiology, although not yet determined, probably involves genetic, immunological and infectious mechanisms. The recurrent multifocal osteomyelitis, an inflammatory disease, can be associated with this syndrome even as a single event. Case Report A c...

Abstract: SAPHO syndrome is characterized with a set of symptoms including skin lesions, osteoarticular manifestations like aseptic osteitis (of the anterior chest wall or other skeletal sites), peripheral synovitis. Due to lack randomized clinical trials and low prevalence condition, there are no established treatment guidelines for syndrome. Here, we report case sternum palmoplantar pustulosi...

Purpose: Demonstrate the possible manifestations of SAPHO syndrome. Material and methods: 38-year-old woman with suspected syndrome were performed scintigraphy SPECT/CT for evaluate localization abundance process. Results: Osteosclerosis hyperostosis left clavicle, osteosclerosis L1 vertebra other, less pronounced changes, accompanied by active accumulation 99mTc-MDP, revealed. Conclusion: It i...

OBJECTIVES To assess serum interleukin-6 (IL-6) and interleukin-23 (IL-23) and their correlation with angiogenic cytokines and disease activity in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and SAPHO syndrome. PATIENTS AND METHODS We studied 152 spondyloarthritis (SpA) patients: 69 PsA, 61 AS, 22 SAPHO, and 29 controls. We recorded age, sex, disease duration, and treatment. We as...