The LFA-1 inhibitor and leukocyte adhesion suppressor BIRT-377 was prepared in high enantiomeric excess by desymmetrization of dimethyl 2-p-bromobenzyl-2-methylmalonate, followed by condensation of the resulting carboxylic acid with 3,5-dichloroaniline, saponification of the remaining ester and Curtius rearrangement as the key steps. When Curtius rearrangement preceded the condensation step, (e...

Novel saponification-triggered gelation in an ester-based bis-salen Zn(II) complex (1) is described. Strategic structural modifications induced by NaOH in 1 tune the dipolar-/π-interactions leading to J-aggregation and the creation of an inorganic gel material (IGM), which has been established by photophysical, DFT and rheological studies.

"777 oil" a coded drug of Siddha system of medicine was prepared and analyzed in the paper. The drug showed 3.62, 13.57 and 266.9 Iodine value, acid number and saponification number respectively. The bark which was one of the ingredients in the drug was possessing 0.63% nitrogen in the acid soluble portion. The bark also exhibited proeolytic activity and the optimum pH was 4.

Pheophytins esterified with phytol and tetrahydrogeranylgeraniol are isolated from etiolated oat seedlings after short (1 min) exposure to light and a subsequent dark period of 15 to 20 min. After saponification of the pheophytins, a mixture of the alcohols was isolated. The structure of tetra­ hydrogeranylgeraniol was established as 3,7,11,15-tetramethyl-zl2’14 hexadecadiene-l-ol (3a). The imp...

The article compares mechanical parameters, group chemical compositions, iron content, lipid compositions before and after saponification, moisture, bulk density in three parts of Betula pubescens Ehrh. birch wooden parts: sapwood, false heartwood, heartwood border. strength properties the are worse than those sapwood. border core is sometimes stronger that other parts. Evaluation carried out t...