The frequency of peripheral nerve involvement in sarcoidosis is uncertain. To determine how often peripheral nerves are affected in the absence of symptoms, electromyography was performed on 29 sarcoid patients and 29 age-matched controls. Nineteen sarcoid patients, compared to two controls, had abnormally low sensory amplitudes in one or more nerves, and the mean sensory amplitudes for median,...

The recent case of necrotising sarcoid granulomatosis described by ALIBERTI et al. [1] provides clinicians with an interesting insight into this rare condition. We would like to supplement the paucity of literature surrounding necrotising sarcoid granulomatosis and illustrate a case of our own. This was also in a young patient but did require treatment with oral corticosteroids at initial prese...

Boeck's sarcoid frequently produces widespread roentgenologic evidence of pulmonary disease without clinical signs or symptoms. Wright and Filley (1) reported normal pulmonary function studies in one such case. Others (2, 3, 4, 5) have reported a variety of effects of more advanced sarcoidosis on pulmonary function. This report is a study of pulmonary function in six cases of Boeck's sarcoid an...

The clinical significance of sarcoid-like granulomata in recurrent Crohn's disease has been investigated in 90 patients. The recurrence rate for non-granulomatous disease was double that of granulomatous disease. In granulomatous disease, involvement of the mesenteric lymph nodes did not affect the recurrence rate. This suggests that sarcoid-like granulomata reflect the patients' immune respons...

Right-heart overload happens relatively rarely in sarcoidosis, even with fibroemphysematous changes. Of 21 cases that we studied, six (28%) had clinical and/or electrocardiographic features of cor pulmonale. The cause of cor pulmonale often evoked is an invasion of the walls of pulmonary vessels by sarcoid granulomas or their compression by the fibrotic process. Pathological studies in one pati...

Pleural effusion in sarcoidosis is infrequent. The data on thoracoscopic observations of sarcoidosis pleurisy are limited. The present study describes three cases of sarcoid-related pleurisy diagnosed by medical thoracoscopy and discusses the thoracoscopic features of sarcoid pleuritis. The appearance of pleural nodules was completely different in the three cases, and the distribution of nodule...

Sarcoidosis reflects a multisystem granulomatous disease of unknown etiology that is characterized by the formation of non-caseating granuloma in various organs. Cardiac involvement may occur in one out of four patients accounting for an increased mortality rate in these patients. F-fluorodeoxyglucose-positron emission tomography( F-FDG-PET)is increasingly applied for the detection and characte...

Sarcoidosis is a chronic granulomatous disease that can affect multiple organs. The lungs, eyes, and skin are known to be highly affected organs in sarcoidosis. There have been reports based on random muscle biopsy that 32-80% of systemic sarcoidosis comprises noncaseating granulomas; however, muscle involvement in sarcoidosis is generally asymptomatic and has an unknown frequency. We describe ...

Sarcoidosis is a chronic multisystem disease of unknown cause that seldom occurs in children; however cases of pediatric sarcoidosis have been reported in India(l). There has been considerable progress in the understanding of this disease since Kendig(2) published an article in 1962. Most commonly the lungs, lymph nodes, skin, liver and spleen are involved, but sarcoid granulomata have been fou...

Macrophages produce various arachidonic acid (AA) metabolites which may either enhance or suppress inflammatory processes. We investigated AA metabolite production by alveolar macrophages (AMs) from 11 patients with pulmonary sarcoidosis and 9 normal volunteers. We assessed the production of both cyclooxygenase products (prostaglandin (PG) E2, thromboxane B2 (TXB2), PGF2 alpha, and 6-keto-PGF1 ...