This paper reviews involvement of the serotonergic system in the control of food intake and satiety. It is of great interest to understand the relevance of this system for physiological control of energy balance and obesity. Over 35 years of research suggest that serotonin (5-HT) plays an important role in satiety. Thus, the serotonergic system has been a viable target for weight control. The 5...

The principal reason that influences people’s eating characteristics is to satisfy basic body stimuli, like feeling hunger and the need for satiety [...]

Tumor-induced reduction in food intake in 2 rat-tumor organisms was distributed approximately equally between reduction in average size (premature satiety) and reduction in frequency (impaired perception of hunger) of effective meals. In both organisms, the frequency of futile meals (activity at food dish without any food ingestion) increased in the tumor-bearing state, and total meal frequency...

The control of food intake and satiety requires a coordinated interplay. Oral protein and duodenal fat inhibit food intake and induce satiety, but their interactive potential is unclear. Our aim was therefore to investigate the interactions between an oral protein preload and intraduodenal (ID) fat on food intake and satiety feelings. Twenty healthy male volunteers were studied in a randomized,...

This short overview considers a prospect that claims to boost satiety are used to prescribe or sell materials to dieters that do not slow their daily rate of energy intake, thereby worsening their problems with body weight and even perhaps increasing the prevalence of obesity. Implying that a drug or a food contributes to weight control by providing extra satiety is a mistake in two ways. First...

Our olfactory sense plays an important role in eating behavior by modulating our food preferences and intake. However, hunger or satiety may also influence how we perceive odors. Albeit speculative, contradictory results found in the past may have resulted from confounding by type of meal that participants ate to induce satiety. We aimed to investigate the influence of hunger state on olfactory...

BACKGROUND Dietary fibers are associated with enhanced satiety. However, the mechanism of different dietary fibers contributing to satiety-related gastrointestinal (GI) peptide release, especially in an obese population, is still poorly understood. Polydextrose (PDX), a water-soluble glucose polymer, has demonstrated its ability to reduce energy intake at a subsequent meal, but its mechanism of...

The drive to eat is controlled by neuronal circuits in the hypothalamus that respond to hormones signaling hunger or satiety. In this issue of Cell, Yang et al. (2011) reveal an AMPK-dependent synaptic pathway that sustains excitatory stimulation of the NPY/AgRP neurons that promote feeding behavior until satiety signals kick in.