Defects of mitochondrial DNA have been found at necropsy in the myocardium of patients with Kearns-Sayre syndrome. A patient with characteristics typical of Kearns-Sayre syndrome and a complete heart block is described. Southern blot analysis showed a deletion of 3.3 kb in the mitochondrial DNA in an endomyocardial biopsy specimen and in skeletal muscle. The deletion led to the disappearance of...

When mitochondrial diseases result from mutations found in the mitochondrial DNA, engineered mitochondrial-targeted nucleases such as mitochondrial-targeted zinc finger nucleases are shown to specifically eliminate the mutated molecules, leaving the wild-type mitochondrial DNA intact to replicate and restore normal copy number. In this issue, Gammage and colleagues successfully apply this impro...

Humean passions are of, for or about things – that is, they are intentional. However, Hume is also taken to claim, in a famous passage of A Treatise of Human Nature, that the passions do not represent anything (THN 2.3.3.5). Hume’s views in 2.3.3.5, and his views on intentionality of the passions, have been interpreted to be in tension with each another (Kenny 2003, Penelhum 1993, Cohon and Owe...

In the paper by Sayre [Acta Cryst. (2008), A64, 33-35], a proposal is made to use stereoscopy as a short-term means of overcoming the primarily technological hurdles involved in three-dimensional imaging of the biological cell by soft X-ray diffraction microscopy. This addendum provides a broader perspective on the techniques used by this rapidly maturing community to investigate structural pro...

27. Foutz RA, Sayre MR. Automated external defibrillators are cost effective. Prehosp Emerg Care. 2000;4:314–317. 28. Pell JP, Sirel JM, Marsden AK, et al. Potential impact of public access defibrillators on survival after out-of-hospital cardiopulmonary arrest: retrospective cohort study. BMJ. 2002;325:515–519. 29. Zipes DP. Saving time saves lives. Circulation. 2001;104:2506–2508. 30. Eisenbe...

The purpose of this research was twofold. First, to determine if eight Multidimensional Health Locus of Control types hypothesized by Wallston and Wallston (1982) existed. Second, to assess the reliability, validity, and clinical utility of the control types. Two investigations were conducted based on research procedures designed for the discovery of clusters. The first study involved the deriv...

This is a book, as the title suggests, primarily concerned with the history of range science and particularly the development of range science in the USA. That said, it has much to offer Pastoralism readers as it provides fresh insights into a number of the different concepts that underlie rangeland management and assessment globally that continue to directly affect pastoral livelihoods. The bo...