A well described case in the Christmas tradition is that of Patient R, reported to have been afflicted with a very shiny nose. The lesion was described as having a lustrous, glowing appearance and initially exerting a significant burden on quality of life — the patient’s peers engaged in name-calling and excluded him from social games. It would seem that the case proved a challenge diagnostical...

We present a sixty three year old female with erythematous itching rash over the lower limbs since 4 years, rash over abdomen since 2 years, rash over forehead and scalp since 1 year. She denied any other systemic complaints. Clinically she had pallor and well defined erythematous, hyperpigmented plaques over the shin bilaterally, symmetrical with few depigmented areas over the lower aspect of ...

A 30-year-old Caucasian woman with history of chronic active systemic sarcoidosis for 14 years, presented at our dermatology department complaining of recurrent ulcerative papules and nodules that had begun four years ago. Sarcoidosis, involving the lungs, lymph nodes, kidney (interstitial nephritis), skin (pannicu-litis) and eyes (uveitis), was diagnosed by ganglionar and renal biopsy and trea...

  Sarcoidosis is a multisystem noncaseating granulomatous disease with a propensity for lung, eye, and skin which recently have been proposed that mycobacterium tuberculosis may contribute in its pathogenesis, and rarely involves central nervous system (CNS). Despite CD4+ lymphocytopenia, sarcoidosis by itself does not increase risk of opportunistic infections other than cryptococcosis.Nonethel...

sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. it is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. the balance between th1, th17 and regulatory t(treg) cells controls t-cell proliferation and activation.the th17/treg ratio in the peripheral blood and bronchoalveolar lavage fluid...

background: sarcoidosis is a multisystem inflammatory disease of unknown origin with characterization of small granulomas. angiotensin-converting enzyme (ace) is a pathophysiologic marker of sarcoidosis. we present the ace insertion/deletion (i/d) polymorphism in correlation with serum ace level in iranian patients with sarcoidosis. methods: from jan 2014 to jan 2015, 102 iranian patients who h...

Background: Sarcoidosis is a multisystem granulomatous disease. Co-existence with spondyloarthritis (SA) has been more described as an adverse effect of anti-TNF α therapy than an association. We report herein a case of a typical sarcoidosis confirmed by histological proofs and an advanced SA with a bamboo column. Case Presentation: A 48-years-old woman presented with inflammatory back p...

Background: In 10-30% of the cases with sarcoidosis, skin lesions appear solely without any systemic signs or symptoms. BTNL2 gene, which is a member of the immunoglobulin gene super family and is associated with CD86 and CD80 co-stimulatory receptors, is identified to play an important role in the establishment of sarcoidosis. We aimed to evaluate the role of this gene in patients with skin sa...