Improvements in image quality and quantitation measurement, and the addition of detailed anatomical structures are important topics for single-photon emission tomography (SPECT). The goal of this study was to develop a practical system enabling both nonuniform attenuation correction and image fusion of SPECT images by means of high-performance X-ray computed tomography (CT). A SPECT system and ...

UNLABELLED The aim of this study was to elucidate the clinical usefulness of scatter correction with an artificial neural network (ANN) in 99mTc and 123I dual-isotope SPECT. METHODS Two algorithms for ANN scatter correction were tested: ANN-10 and ANN-3 employing 10 and 3 energy windows for data acquisition, respectively. Three patients underwent myocardial or brain SPECT with one of the foll...

Scatter correction is an important factor in single photon emission computed tomography (SPECT). Many scatter correction techniques, such as multiple-window subtraction and intrinsic modeling with iterative algorithms, have been under study for many years. Previously, we developed an efficient slice-to-slice blurring technique to model attenuation and system geometric response in a projectorhac...

Introduction: The key characteristics of positron emission tomography (PET) are its quantitative capability and its sensitivity, which allow the in vivo imaging of biochemical interactions with small amounts of tracer concentrations. Therefore, accurate quantification is important. However, it can be sensitive to several physical factors. The aim of this investigation is the assessment of the e...

BACKGROUND Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positron-emission tomography [PET] isotopes such as 124I is promising in that context but requires accurate activity quantification. The decay scheme of 124I implies an optimization of...

The purpose of this study was to evaluate different approaches for scatter artifact reduction in the field of dimensional computed tomography (CT). The methods we investigated can be subdivided into one software-based method and three hardware-based methods. The software-based method uses a Monte Carlo scatter simulation to estimate scatter intensities for an initial model of the geometrical an...

In this paper we present a scatter correction method for a regularized list mode maximum likelihood reconstruction algorithm for the positron emission mammograph (PEM) that is being developed at our laboratory. The scatter events inside the object are modelled as additive Poisson random variables in the forward model of the reconstruction algorithm. The mean scatter sinogram is estimated using ...

Purpose: The aim of this study is to evaluate the impact of different scatter correction strategies on quantification of high-resolution research tomograph (HRRT) data for three tracers covering a wide range in kinetic profiles. Procedures: Healthy subjects received dynamic HRRT scans using either (R)-[C]verapamil (n=5), [C]raclopride (n=5) or [C]flumazenil (n=5). To reduce the effects of patie...

2 Cover illustration: The logarithm of a 123 I point spread function. The point source was simulated at 14.0 cm distance from the collimator in air, with the SIMIND version described in Paper V, using parameters corresponding to a GE Millennium MPR with 2.3 × 2.3 m 2 field of view. The grey scale is processed. To Björn, family and friends If you don't care where you are, you ain't lost. ABSTRAC...