BACKGROUND Henoch-Schönlein purpura (HSP) is one of the most common vasculitides in children. It is manifested by skin purpura, arthritis, abdominal pain, renal involvement, etc. Typically, HSP is considered to be self-limiting, although renal involvement (HSP purpura nephritis, HSPN) is the principal cause of morbidity from this disease. For this reason, it is important to clarify the mechanis...

Acute hemorrhagic edema of young children is a rare leukocytoclastic small-vessel vasculitis that was initially described in 1913 by Snow in the United States and in 1936 by Del Carril in Argentina. The condition was also reported by Finkelstein and by Seidlmayer in Germany before the Second World War, and by Lelong in France in 19421,2. The disorder, considered by some the infantile variant of...

A 61-year-old woman presented with acute lower abdominal pain, bloody diarrhea, and purpura on the right thigh (●" Fig.1). Urgent sigmoidoscopy revealed edema and multiple hyperemic ecchymotic lesions in the sigmoid colon and rectum (●" Fig.2), which appeared reddish on viewing with conventional white light and cyan on narrow-band imaging (NBI) (●" Fig.3). These lesions were indicative of bleed...

BACKGROUND Henoch-Schönlein purpura is a common vasculitis of childhood affecting the skin, joints, gastrointestinal tract, and kidney. The mesangial deposition of IgA1 is the most critical factor for the prognosis of patients with this disease. The aberrant glycosylation of the IgA1 subclass with the absence of terminally located galactose and presence of only alpha-N-acetylgalactosamine in O-...

Henoch-Schönlein Purpura (HSP) is a systemic vasculitis mediated by IgA and characterized by the clinical triad of non-thrombocytopenic palpable purpura, abdominal pain, and arthritis. In addition, there may be varying degrees of renal involvement. It is the most frequent vasculitis in children and the incidence in adults varies from 3.4 to 14.3 cases per million, depending upon the experimenta...

The clinico-pathological features of 133 consecutive cases of Henoch-Schönlein purpura are presented, with emphasis on the gastrointestinal manifestations. The potential pitfalls of contrast radiography are underlined with respect to management of intussusception and a plea is made to re-establish clinical assessment of the abdomen as the prime indicator in deciding to undertake laparotomy.