Scorpion venoms have been studied for decades, leading to the identification of hundreds of different toxins with medical and pharmacological implications. However, little emphasis has been given to the description of these arthropods from cellular and evolutionary perspectives. In this report, we describe a transcriptomic analysis of the Mexican scorpion Centruroides noxius Hoffmann, performed...

background: immunotherapy is the only specific treatment for scorpion envenomation. in the present study, the protective effects of polyvalent antivenom against histopathological complications in kidneys and marker changes (bun and creatinine) induced by mesobuthus eupeus (me) scorpion venom was investigated in anesthetized rabbits. methods: twenty four rabbits were randomized into four groups:...

Background: Increasing antimicrobial resistance of microbes is one the leading challenges faced by medical community and human health. This study focused on a local scorpion species (Buthus sindicus) Pakistan known for its potent antibiotic properties against Carbapenem-resistant Acinetobacter baumannii Pseudomonas aeruginosa. Methodology: Venom extracted from Buthus sindicus tested A. P. aerug...

Centruroides tecomanus is a Mexican scorpion endemic of the State of Colima, that causes human fatalities. This communication describes a proteome analysis obtained from milked venom and a transcriptome analysis from a cDNA library constructed from two pairs of venom glands of this scorpion. High perfomance liquid chromatography separation of soluble venom produced 80 fractions, from which at l...

Specific anti-venom used to treat scorpion envenomation is usually obtained from horses after hyperimmunization with crude scorpion venom. However, immunized animals often become ill because of the toxic effects of the immunogens used. This study was conducted to evaluate the toxic and immunogenic activities of crude and detoxified Tityus serrulatus (Ts) venom in sheep during the production of ...

The three-disulfide inhibitor cystine knot (ICK) motif is a fold common to venom peptides from spiders, scorpions, and aquatic cone snails. Over a decade ago it was proposed that the ICK motif is an elaboration of an ancestral two-disulfide fold coined the disulfide-directed β-hairpin (DDH). Here we report the isolation, characterization, and structure of a novel toxin [U(1)-liotoxin-Lw1a (U(1)...

androctonus crassicauda is the second most frequent causes of scorpion sting in south-west iran. its venom can cause sever pain, autonomic, central nervous system (cns), muscle function disturbances, and death. appropriate medi­cal and nursing cares can lead to complete recovery with no sequel .the majority of scorpion stings are oligosympto­matic, occurring mainly on the hands and feet (about ...

The anti scorpion venom activity of the Indian medicinal plant (Hemidesmus indicus, Pluchea indica and Aristolochia indica) root extracts (aqueous and methanol) was established in experimental animal models. Adult black scorpions (Heterometrous bengalensis) of both sexes were collected and the Scorpion Venom (SV) was collected by electrical stimulation, pooled, lyophilized and stored at 4 °C. S...

introduction: scorpion venom is a source of bioactive peptides, and some antimicrobial peptides (amps) have been found in the venom gland of scorpions. therefore, the discovery of new anti-infective agents is an essential need to overcome the problem of antibiotic resistance of clinical isolates. here, we describe three new cationic amps, including meuvap-6, meuap-18-1, and meupep34 from the ve...

The venom of the South African scorpion Parabuthus transvaalicus was characterized using a combination of mass spectrometry and RP-HPLC separation and bioassays. The crude venom was initially separated into 10 fractions. A novel, moderately toxic but very high abundance peptide (birtoxin) of 58 amino-acid residues was isolated, identified and characterized. Each purification step was followed b...