background: apelin is a mitogenic peptide; it has functions in vessel formation and cell proliferation. in this study we aimed to evaluate the serum and tissue levels and local expression pattern of apelin in eutopic and ectopic endometrium from patients with and without endometriosis and to compare the proliferative and secretory phase differences. methods: thirty women with endometriosis and ...

Endometrial cancer is the most common gynecological in developed countries, second poor countries and developing after cervical cancer. Most endometrial patients come with complaints of bleeding at an early stage. It’s important to make right diagnosis determine appropriate treatment. Treatment depends on stage determined by surgery. After surgery, patient’s risk was classified as low, moderate...

Objective: To investigate the expression of receptor for advanced glycation endproducts (RAGE) in adenoid hypertrophy in children and the change in the level of soluble receptor for advanced glycation endproducts (sRAGE) in tympanic effusion. Methods: Fifteen adenoidal specimens were collected from patients with adenoidal hypertrophy and secretory otitis media and patients with simple adenoidal...

We have investigated the sorting and packaging of secretory proteins into secretory granules by an immunological approach. An mAb against secretogranin I (chromogranin B), a secretory protein costored with various peptide hormones and neuropeptides in secretory granules of many endocrine cells and neurons, was expressed by microinjection of its mRNA into the secretogranin I-producing cell line ...

AIMS To evaluate serum secretory component in relation to early detection and clinical management of liver metastasis in patients with colorectal cancer. METHODS Secretory component and carcinoembryonic antigen (CEA) were analysed in serial serum samples from 23 patients who had liver metastases as the only apparent recurrence, and in sera from 54 matched controls. Results of surgical treatme...

Secretory vesicles are neutrophil intracellular storage granules formed by endocytosis. Understanding the functional consequences of secretory vesicle exocytosis requires knowledge of their membrane proteins. The current study was designed to use proteomic technologies to develop a more complete catalog of secretory vesicle membrane proteins and to compare the proteomes of secretory vesicle and...

The regulated Cl(-) secretory apparatus of T84 cells responds to several pharmacological agents via different second messengers (Ca(2+), cAMP, cGMP). However, information about water movements in T84 cells has not been available. In the absence of osmotic or chemical gradient, we observed a net secretory transepithelial volume flux (J(w) = -0.16 +/- 0.02 microl.min(-1).cm(-2)) in parallel with ...