pet (positron emission tomography) is a powerful imaging technique that can provide quantitative information on the distribution of positron emitter labeled radiopharmaceuticals (pet radiopharmaceuticals) in the body. positrons (ß+) are positively charged beta particles. they are emitted when the atom is proton rich. a positron has only a transient existence. after losing all of its kinetic ene...

Objective: Radiopharmacy is a special field of pharmacy that examines, develops, conducts quality controls, deals with distribution and application pharmaceutical forms called radiopharmaceuticals are used for diagnostic therapeutic purposes, carrying radioactive properties together. Radiopharmaceuticals contain radionuclides. This the most important difference distinguishes from other conventi...

Nuclear medicine techniques (single photon emission computerized tomography, SPECT, and positron emission tomography, PET) represent molecular imaging tools, able to provide in vivo biomarkers of different diseases. To investigate brain tumours and metastases many different radiopharmaceuticals imaged by SPECT and PET can be used. In this review the main and most promising radiopharmaceuticals ...

The folate receptor (FR) is overexpressed on a variety of tumor types, whereas its distribution in normal tissues and organs is highly limited. Exploration of the utility of the FR revealed its promising potential for targeting with folate-based radiopharmaceuticals. Herein, we report the principle of the FR-targeting strategy and summarize the development of several folic acid radioconjugates ...

Pediatric malignancies are relatively rare and account for 0.5% of all cancers. The annual incidence varies between 110 and 150 per million children, which means that the chance for a child to develop a cancer during the first 15 years of life is 1:450–600. Leukemias and tumors of the brain and spinal cord have the highest relative incidence rates, followed in frequency by neuroblastoma, lympho...