A 4-year-old previously healthy and fully immunized boy presents with a 2-day history of sore throat and a 1-day history of fever and drooling. He awakened today with worsening sore throat, drooling, and subjective fever. He complains of pain during swallowing and refuses oral intake. He has no cough, congestion, sick contacts, or recent travel. His prenatal, natal, and postnatal histories cont...

Uterine inflammation occurs after calving in association with extensive endometrial remodelling and bacterial contamination. If the inflammation persists, it leads to reduced fertility. Chronic endometritis is highly prevalent in high-yielding cows that experience negative energy balance (NEB) in early lactation. This study investigated the effect of NEB on the antimicrobial peptides S100A8 and...

The effects of dietary supplementation of selenium (Se), iodine (I), and a combination of both on the blood haematology, serum free thyroxine (FT4) and free triiodothyronine (FT3) hormones and glutathione peroxidase enzyme (GSH-Px) activity were examined on twenty four (7 to 8 months old, 22±1.17 kg live weight) Kacang crossbred male goats. Animals were randomly assigned to four dietary treatme...

The Lamin B receptor (LBR) is a pivotal architectural protein in the nuclear envelope. Mutations in the Lamin B receptor lead to nuclear hyposegmentation (Pelger-Huët anomaly). We have exactly quantified the nuclear lobulation in neutrophils from individuals with 0, 1, 2 and 3 functional copies of the lamin B receptor gene and analyzed the effect of different mutation types. Our data demonstrat...

Neutrophilic-chronic myelogenous leukemia (CML-N) is a rare chronic myelogenous leukemia (CML) variant characterized by BCR-ABL1 positive chronic neutrophilia. It has a BCR breakpoint on chromosome 22 between exons 17 and 20 in a region designated as micro-BCR. It is thought to have a more benign course than classical CML. This case report describes a 41-year-old Saudi woman diagnosed with CML-...

The present study evaluated the effects of single-dose filgrastim on hematology in 16 healthy horses after long-distance transportation. Horses were assigned to receive filgrastim (0.23 µg/kg, SC, once; G-CSF group; n=8) or saline (0.9% NaCl) solution (0.3 ml, SC, once; control group; n=8) ≤ 1 hr before transportation. Horses were transported 2,530 km using commercial vans over the course of ap...

Macrocytosis, generally defined as a mean corpuscular volume greater than 100 fL, is frequently encountered when a complete blood count is performed. The most common etiologies are alcoholism, vitamin B12 and folate deficiencies, and medications. History and physical examination, vitamin B12 level, reticulocyte count, and a peripheral smear are helpful in delineating the underlying cause of mac...

A 4-year-old girl with Crohn disease (CD) was repeatedly hospitalized for exacerbation of CD. She was treated with oral tacrolimus, prednisolone, methotrexate, and 6-mercaptopurine. Additionally, total parenteral nutrition was administered through a central venous catheter (CVC). After four months from the CVC was placed, she developed a fever of 39.3 C, hypotension (84/ 42 mmHg), sinus tachyca...

A 2-month-old girl, who was current on her immunizations and had no prior illness, presented to the emergency department with a 2-week history of progressive cough and shortness of breath. A chest radiograph revealed bilateral peribronchial thickening. Complete blood count results revealed a white blood cell count of 38.6 3 10/L (71% lymphocytes, 19% segmented neutrophils, 6% monocytes, 3% band...

The dog had a history of abdominal pain and vomiting of five days duration. An umbilical hernia had been surgically repaired years earlier. The dog was depressed, lethargic, and had painful palpations of the cranial abdomen. Body temperature (39"C), heart rate (1 10 bpm) and respiratory rate (44 breathdmin.) were normal. Heart sounds were clearly audible on the right side and muffled on the lef...