A 58-year-old man presented with a history of disturbance in initiating gait. His history revealed meningoencephalitis five years prior to admission. Neurological examination included gait disturbance as difficulty in initiation and a hesitating speech with many freezing episodes and micrographia Magnetic resonance imaging (MRI) showed diffuse hyperintensity of frontal subcortical white matter ...

10.2217/14750708.5.2.203 © 2 Parkinson’s disease is a neurodegenerative disorder manifested by a combination of motor and non-motor symptoms. Levodopa, a dopamine precursor, is the most efficacious drug available to control the symptoms of Parkinson’s disease. Almost all other medications with symptomatic benefit for Parkinson’s disease show their effect by facilitating the dopaminergic system,...

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Although the CYP content of brain is too low to significantly influence the overall pharmaco-kinetics of drugs and hormones in the body, brain CYP could play a role in tissue-and/or cell-specific sensitivity to certain drugs or xenobiotics. We have characterized the CYP-dependent metabolism of l-deprenyl by brain microsomal preparations obtained from different experimental animals: monkey, C57B...

Six hundred forty-one dogs with clinical signs consistent with canine cognitive dysfunction syndrome (CDS) were treated orally with selegiline hydrochloride at 0.5 to 1.0 mg/kg once daily for 60 days. Response to selegiline treatment on days 30 and 60 were similar. On day 60, 77.2% of dogs showed an overall improvement; response to treatment by clinical sign ranged from 67.8% (activity or sleep...

S t u d y s e l e c t i o n Studies were selected if they were unconfounded, randomized, double-blind, controlled trials that compared selegiline with placebo in patients with Alzheimer disease. Studies had to have been reported before the end of 1998; patients had to meet the criteria of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease a...

The first effective drugs for Parkinson's disease (PD) were anticholinergics, introduced at the end of 19.th century by Charcot. Since the introduction of levodopa in the sixties of the previous century, many new drugs have emerged for the treatment of Parkinson's disease: dopamine agonists (ergot as well as non-ergot, bromocriptine, pergolide, mirapexine, ropinirole), MAO B inhibitors (selegil...

Background: No single pharmacologic treatment has proven effective for the symptomatic management of progressive supranuclear palsy. Methods: We report a case of postural instability and falls secondary to PSP of the Parkinson's subtype and initial monotherapy with donepezil 10 mg daily for 3 months followed by a novel investigation of selegiline in combination for 6 additional months. Fall fre...