Background Telitacicept (TACI-Fc fusion protein) is a novel BLyS (B-lymphocyte stimulator)/APRIL (a proliferation-inducing ligand) dual inhibitor, which has been approved in 2021 China for the treatment of patients with active systemic lupus erythematosus (SLE)[1]. Objectives Assess efficacy and safety telitacicept SLE double-blind, randomized, placebo-controlled, phase 3 trial. Methods In this...

We report the optical characterization of near-infrared (NIR) emitters for polymer light-emitting diode (PLEDs) applications based on the copolymerization of a phthalimide-thiophene host polymer with a low-gap emitter containing the bisthienyl(benzotriazolothiadiazole) unit. We investigate different loadings of the low-gap emitter (in the range 1–3% by weight) and the substitution of a sulphur ...

Beauty products use social media to advertise their get people know them. To attract the audience, advertisers need reflect sentence types as well titles marketing approach. Understanding essential for company reach targeted market. This research studied of positive beauty campaign YouTube advertisements. The data collecting technique is through document review by using converted spoken utteran...

Abstract Background and Aims Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease of unknown aetiology affecting various organs tissues. In the last decade, alternative therapeutic methods for SLE refractory to immunosuppressive therapy have been actively studied. Of interest are data transplantation mesenchymal stem cells (MSCs) that demonstrated immunomodulatory prop...

Background: In the management of patients with Systemic Lupus Erythematosus (SLE), it is utmost importance to accurately identify lupus flares. There a conceptual consensus definition flares [1]; however, instruments used in clinical trials, such as SELENA Flare Index (SFI) are too cumbersome apply daily practice. The SLE disease activity score (SLE-DAS) validated continuous measure higher sens...

The first complete overview of the African fauna Lispe is published. paper consists 3 parts. (1) alphabetical list 55 taxa given with references, distribution data and, where necessary, taxonomic remarks or descriptions. (2) Addendum 26 which are not included in main (as synonymies for other reasons). (3) Identification key Africa. illustrated 47 figures. Six new described: alkaline sp. nov.; a...

In this study, we analyzed the newly emerging research field of climate change in combination with tea production. We adapted a valid search query to cover the relevant literature as completely as possible and to exclude irrelevant literature. The search resulted in a publication set of 14 key papers dealing with the implications of climate change for tea production as well as 71 papers citing ...