©2010 Particle Sciences, Inc. All rights reserved. centrifugation is a highly accurate technique, but it is not amenable to use with semisolid formulations with high viscosities. All the methods discussed so far may require dilution and while some drug product formulations can be diluted without changing the particle size distribution, others may be affected by dilution, which makes meaningful ...

Mouth dissolving film is the most advanced oral solid dosage form due to its flexibility and comfort in use. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. This dosage form allows the medication to bypass the first pass metabolism so bioavailability of medication may be improved .Mouth dissol...

Most of the antibiotics were originally derived from micro-organisms while the chemotherapeutic agents are from plants. Herbal medicine refers to the use of any plant's seeds, berries, roots, leaves, bark, or flowers for medicinal purposes. Along with other dosage forms, herbal drugs are also formulated in the form of ointment. An ointment is a viscous semisolid preparation used topically on a ...

BACKGROUND There is at present no agreement on the type of test meal to be used when performing EGG. To our knowledge the response of the stomach to high carbohydrate isocaloric meals of different consistencies has not been formally assessed. AIM To study 1) the effects of high carbohydrate meals of varying consistency on EGG activity; and 2) the effects of increasing the calorie content of a...

Welin-Berger, K., 2001. Formulations, Release and Skin Penetration of Topical Anesthetics. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 258. 53 pp. Uppsala. ISBN 91-554-5115-2. This thesis describes certain critical aspects of the development of semisolid topical anesthetic formulations requiring a fast onset of action. Furthermor...

VCO (virgin coconut oil) has benefits for skin health such as softening the skin, maintaining health, and protecting from radiation free radicals. one of raw materials making cream preparations can affect its physical stability. This study aimed to analyze effect on stability sweet potato leaf extract creams antibacterial activity test against Staphylococcus aureus ATCC 25923. The were made wit...

Ocular diseases may be treated via different routes of administration, such as topical, intracameral, intravitreal, oral and parenteral. Among them the topical route is most accepted by patients, although it provides in many cases lowest bioavailability. Indeed, when a formulation reaches precorneal area, i.e., drug absorption and/or action site, rapidly eliminated due to eye protection mechani...

This investigation describes the formulation and characterization of rheologically structured vehicles (RSVs) designed for improved drug delivery to the vagina. Interactive, multicomponent, polymeric platforms were manufactured containing hydroxyethylcellulose (HEC, 5% w/w) polyvinylpyrrolidone (PVP, 4% w/w), Pluronic (PL, 0 or 10% w/w), and either polycarbophil (PC, 3% w/w) or poly(methylvinyl...

pastes, cream emulsions, gels, and rigid foams. Their common property is the ability to cling to the application surface for a reasonable period of time before they are washed off or worn off. They usually serve as vehicles for topically applied drugs, as emollients, or as protective or occlusive dressings, or they may be applied to the skin and membranes such as the rectal, buccal, nasal, and ...