Background: Leptomeningeal disease occurs in 3-5% of patients with lung cancer, mainly adenocarcinoma subtype. Adenocarcinoma is the most common histological finding Asian women.
 Case: A 51-year-old woman right-sided bronchogenic T4N3M1c Std IVB mutation(+) developed decreased vision, severe bilateral sensorineural deafness and psychiatric disorders after receiving Gefitinib 15 months. Th...

Sensorineural deafness and retinitis pigmentosa (RP) are the hallmarks of Usher syndrome (USH) but are also prominent features in peroxisomal biogenesis defects (PBDs); both are autosomal recessively inherited. The firstborn son of unrelated parents, who both had sensorineural deafness and RP diagnosed as USH, presented with sensorineural deafness, RP, dysmorphism, developmental delay, hepatome...

BACKGROUND Hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR) syndrome is an autosomal dominant disorder. We report the first detailed case of hypoparathyroidism complicated by biliary atresia. CASE PRESENTATION A 1-year-old Japanese girl was admitted to our hospital for living donor liver transplantation. She suffered from obstructive jaundice owing to biliary atresia. She...

: Varicella, or chickenpox, is a highly contagious disease transmitted by the varicella zoster virus (VZV). Idiopathic sudden sensorineural hearing loss (ISSNHL) has been defined as of at least 30 dB over three frequencies on audiogram within days and with an uncertain cause. Deafness caused varicella-zoster occasionally occurred in Ramsey hunter syndrome but associated chickenpox rare. We pres...

A 48-year-old Chinese woman presented with progressive right-sided sensorineural hearing loss. Computerised tomography showed asymmetrical widening of the right internal acoustic canal. Post-gadolinium magnetic resonance images demonstrated marked enhancement of an intracanalicular tumour. The diagnosis of acoustic neuroma was confirmed surgically. The approach to imaging of deafness, particula...

Hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome is an autosomal dominant genetic disorder characterized by hypoparathyroidism, sensorineural deafness and renal dysplasia. We herein present the first Turkish patient with HDR syndrome, who has a p.R367X mutation. This report indicates that p.R367X is not a mutation specific for the Far Eastern populations and also that urological ...

An epidemiological and genetic study of profound deafness has been undertaken in the governorate of Nabeul in Tunisia. This paper deals with sensorineural deafness with no associated abnormalities. The prevalence was estimated to be 0.0007 and four clusters could be identified, two of which represent 51% and 34% respectively of the total number of cases. Segregation analysis performed in 29 ped...

Acute sensorineural hearing loss may appear in some autoimmune diseases. Authors presented a case of 31 years old pregnant woman with Leśniowski-Crohn disease, in who acute total deafness of one ear and sensorineural hearing loss in the second ear appeared after she got pregnant. Immunological etiology was confirmed by presence of antinuclear and anti-type II collagen antibodies. Hearing level ...