BACKGROUND Spinal anesthesia is widely used for caesarean section. Addition of intrathecal magnesium sulfate to local anesthetics seems to improve the quality of block and prolong the duration of analgesia. OBJECTIVES The present study was designed to examine whether addition of intrathecal magnesium sulfate enhances the analgesic efficacy of intrathecal bupivacaine in patients undergoing ces...

in asthmatic subjects there is a pronounced diurnal variation in bronchial responsiveness. if this phenomenon is due to variation in factors that control drug delivery, then it should be paralleled by a similar variation in competitive antagonist blockade. in order to study this possibility, we performed the methacholine challenge test and after 45 minutes, administered atropine by inhalation. ...

We examined specific receptor/transmitter combinations used at functionally identified synapses in ascending and descending reflex pathways of guinea pig distal colon. Excitatory (EJPs) or inhibitory junction potentials (IJPs) were recorded intracellularly from nicardipine-paralyzed circular smooth muscle in either the oral or anal recording chamber of a three-chambered organ bath, respectively...

Backgrounds and objectives: This an attempt to compare the effects of 15ml levobupivacaine 0.75%, 20 ml 0.375% 30ml 0.25% with fixed dosage (75mg) on block characteristics in upper limb surgeries using ultrasound guided supraclavicular block. Materials methods: Titled “Comparative study three different volumes concentrations Levobupivacaine block” performed Department Anaesthesiology, Chettinad...

BACKGROUND AND OBJECTIVES To achieve better therapeutic benefits of local anesthetics in the control of postoperative pain through controlled-release carrier. The objective of this study was to compare the characteristics of sensory and motor blockade between microspheres without local anesthetic: racemic bupivacaine-loaded microspheres; 50% enantiomeric excess bupivacaine-loaded microspheres; ...

Background: Peripheral nerve blocks are used as the sole anaesthetic technique to facilitate painless surgery supplemented with monitored anaesthesia care. People have tried mixing local anaesthetic with adjuvant drugs in an attempt to prolong analgesia duration. Aims of this study is to determine the effects of dexamethasone, when added to bupivacaine on the onset, duration of sensory blockade...

We investigated the effects of the sensory neuropeptide substance P (SP) on amylase and fluid secretion in the isolated vascularly perfused rat pancreas. SP inhibited CCK-induced amylase release and secretin-induced juice flow via the pancreatic duct in a dose-related fashion. Threshold inhibition occurred following addition of 10-10 M SP to the perfusate, and maximal inhibition was seen with 1...

Comparison Of Levobupivacaine And Clonidine With Bupivacaine And Clonidine In Spinal anaesthesia ForLowerSegmentCaesareanSection Introduction: Intrathecal LevoBupivacaine is having similar clinical profile with less cardio-toxicity than Bupivacaine is used commonly for LSCS. Clonidine as an additive to LA provides effective, prolonged and dose dependent analgesia. In this study we compared effe...

Repeated intramuscular acid injections produce long-lasting mechanical hyperalgesia that depends on activation of ASICs. The present study investigated if pH-activated currents in sensory neurons innervating muscle were altered in response to repeated acid injections, and if blockade of ASICs reverses existing hyperalgesia. In muscle sensory neurons, the mean acid-evoked current amplitudes and ...