In the present study, we aimed to determine localization and distribution of entero-endocrine cells in gastrointestinal tract by immunohistochemical methods understand structure glycoproteins elaborated epithelium digestive regions histochemical methods. The nine sparrowhawks were euthanized, tissues removed fixed formalin. sections stained with techniques evaluate enteroendocrine histomorphome...

Serotonin is a neurotransmitter with broad functions in brain development, neuronal activity, and behaviors; and serotonin is the prominent drug target in several major neuropsychiatric diseases. The multiple actions of serotonin are mediated by diverse serotonin receptor subtypes and associated signaling pathways. However, the key signaling components that mediate specific function of serotoni...

To determine whether measurement of serotonin in urine would give useful complementary information to the usual measurement of 5-hydroxyindoleacetic acid (5-HIAA) in urine and platelet serotonin in platelets, I measured these analytes in 75 consecutive patients with carcinoid tumors, and found that 75% had above-normal urinary 5-HIAA excretion, 64% had above-normal serotonin excretion, and 64% ...

BACKGROUND Tramadol-induced seizures might be pathologically associated with serotonin syndrome. Here, the authors investigated the relationship between serotonin and the seizure-inducing potential of tramadol. METHODS Two groups of rats received pretreatment to modulate brain levels of serotonin and one group was treated as a sham control (n = 6 per group). Serotonin modulation groups receiv...

  Although cisplatin is one of the most effective cancer drugs which is widely used in the treatment of various neoplasms, its side effects, especially vomiting may limit its use. It has been demonstrated that cytotoxic drugs lead to a sudden release of serotonin (5-HT). The following study was performed to determine the possible interactions of cisplatin with 5-HT receptors. In this study, the...

Caenorhabditis elegans feeds by rhythmically contracting its pharynx to ingest bacteria. The rate of pharyngeal contraction is increased by serotonin and suppressed by octopamine. Using an electrophysiological assay, we show that serotonin and octopamine regulate two additional aspects of pharyngeal behavior. Serotonin decreases the duration of the pharyngeal action potential and enhances activ...

Recent work has shown that chemical release during the fundamental cellular process of exocytosis in model cell lines is not all-or-none. We tested this theory for vesicular from single pancreatic beta cells. The vesicles these cells insulin, but also serotonin, which detectible with amperometric methods. Traditionally, it assumed Here, we use a multidisciplinary approach involving nanoscale me...

In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. ...