INTRODUCTION In critically ill patients sudden changes in glomerular filtration rate (GFR) are not instantly followed by parallel changes in serum creatinine. The aim of the present study was to analyze the utility of serum cystatin C as a marker of renal function in these patients. METHODS Serum creatinine, serum cystatin C and 24-hour creatinine clearance (CCr) were determined in 50 critica...

BACKGROUND Low skeletal muscle mass is associated with deterioration of bone mineral density. Because serum creatinine can serve as a marker of muscle mass, we evaluated the relationship between serum creatinine and bone mineral density in an older population with normal renal function. METHODS Data from a total of 8,648 participants (4,573 men and 4,075 postmenopausal women) aged 45-95 years...

BACKGROUND Reliable serum creatinine measurements in glomerular filtration rate (GFR) estimation are critical to ongoing global public health efforts to increase the diagnosis and treatment of chronic kidney disease (CKD). We present an overview of the commonly used methods for the determination of serum creatinine, method limitations, and method performance in conjunction with the development ...

Prabhat K Nigam*, Abhilash Chandra2 1Department of Cardiology, King George’s Medical University, UP, Lucknow 226004, India Department of Nephrology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Gomti Nagar, Lucknow 226010, UP, India *Author for correspondence: Tel: +919235775577 E-mail: [email protected] Submitted: June 21, 2017 Accepted: July 12, 2017 Published online: July 19, 2017 A...

BACKGROUND AND OBJECTIVES Inaccurate determination of baseline kidney function can misclassify acute kidney injury (AKI) and affect the study of AKI-related outcomes. No consensus exists on how to optimally determine baseline kidney function when multiple preadmission creatinine measurements are available. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS The accuracy of commonly used methods for...

Serum creatinine, a surrogate for both renal function and homocysteine generation, is an important determinant of fasting plasma total homocysteine levels in stable renal transplant recipients. In this study, it is hypothesized that among stable renal transplant recipients with normal creatinine levels (i.e., < or = 1.5 mg/dl), serum cystatin C, a more sensitive indicator of GFR, would better p...

BACKGROUND Serum creatinine and creatinine clearance are used as indicators of renal function and may indicate a propensity for development of end-stage renal disease. Identifying genes related to future decreases in renal function could be important in assessing risk and defining abnormal mechanisms amenable to preventive measures. Although creatinine clearance is a better measure of renal fun...

Recommendations for laboratory diagnosis and monitoring of chronic kidney disease (CKD) state the use of both serum creatinine and cystatin-C in various clinical situations. The relationship of these markers to estimated glomerular filtration rate (eGFR) is found to be different in different populations. In India the routine reporting of eGFR is yet to commence. Meanwhile, the utility of these ...

The composite of end stage renal disease (ESRD), doubling of serum creatinine and (renal) death, is a frequently used endpoint in randomized clinical trials in nephrology. Doubling of serum creatinine is a well-accepted part of this endpoint because a doubling of serum creatinine reflects a large sustained change in glomerular filtration rate (GFR) and predicts the development of ESRD. Although...