Although serum testosterone levels decrease acutely in critically ill patients, estrogen levels rise. We hypothesized that increased rates of aromatization of androgens to estrogens underlie the increase in serum estrogen levels. Eleven men and three women (age 42-69 yr) were prospectively studied before and again after elective coronary artery bypass graft surgery (CABG). Each patient received...

endometriosis is an estrogen dependent disease. levels of cancer antigen-125 are significantly higher in women with moderate to severe endometriosis. however, patients with unruptured endometriosis rarely have serum ca-125 levels more than 1000 u/ml. this case report presents a diffuse, unruptured ovarian endometrioma in a 29- year-old woman, leading to an extraordinary high serum ca-125 and ca...

Objectives : By observing the effect of acupoint catgut embedding on intestinal flora ovariectomized osteoporotic rats, correlation between regulation and prevention treatment osteoporosis was discussed preliminarily. Methods Result: Compared with Group A B, bone mineral density (BMD) femur tibia in C decreased significantly (p<0.05), indicating successful modeling. C, BMD D increased (p<...

Background: The presence of estrogen receptor beta and aromatase in the germ cell has highlighted the physiological role of the traditionally female hormone, estrogen, in spermatogenesis. Estrogen receptor alpha knockouts and aromatase knockouts have further accentuated the role of estrogen in germ cell maturation. To delineate effects of high intratesticular estradiol in the seminiferous epith...

Ovarian estrogen exerts both positive and negative feedback control over luteinizing hormone (LH) secretion during the ovulatory cycle. Estrogen receptor (ER) alpha but not ERbeta knockout mice lack estrogen feedback. Thus, estrogen feedback appears to be primarily mediated by ERalpha. However, it is now recognized that, in addition to binding to estrogen response elements (EREs) in DNA to alte...

The human breast cancer cell line MCF-7 has been adapted to long-term growth at 0.5 and 0.05% fetal bovine serum. Free cytoplasmic and filled nuclear estrogen receptors were found in cells grown at 5, 0.5, and 0.05% fetal bovine serum. Cells grown in medium with 0.05% dextran-charcoal-treated serum contained cytoplasmic receptors but no filled nuclear receptors, indicating that this medium did ...

OBJECTIVE/BACKGROUND Sickle cell disease is a hereditary hemoglobinopathy characterized by abnormal hemoglobin production, hemolytic anemia, and intermittent occlusion of small blood vessels, leading to tissue ischemia, chronic organ damage, and organ dysfunction including endocrine organs. The aim of this work was to evaluate some gonadal hormones in female children with sickle cell anemia (SC...

Background : One of risk factors for increased rate cardiovascular diseases and development menopausal symptoms in perimenopausal/postmenopausal women is reduced estrogen production. Yoga practice improved postmenopausal women. Whether yoga had effect on perinomopausal/postmenopausal was not known. Thus, this study conducted to assess the female hormones; estrogen, progesterone, luteinizing hor...

Abstract Although neutrophils play important roles in immunity and inflammation, their analysis is strongly hindered by short-lived terminally differentiated nature. Prior studies reported conditional immortalization of myeloid progenitors using retroviral expression an estrogen-dependent fusion protein the HoxB8 transcription factor. This approach allowed long-term culture mouse (HoxB8 progeni...