In the present study, we employ our recently developed confocal microscopy-based cell-specific finite element (FE) modeling method, which is suitable for large deformation analyses, to conduct inverse FE analyses aimed at determining the shear modulus of the cytoplasm of cultured skeletal myoblasts, G(cp), and its variation across a number of cells. We calibrate these cell-specific models again...

BACKGROUND The objective of our study was to develop a novel capacitive force sensor that enables simultaneous measurements of yaw torque around the pressure axis and normal force and shear forces at a single point for the purpose of elucidating pressure ulcer pathogenesis and establishing criteria for selection of cushions and mattresses. METHODS Two newly developed sensors (approximately 10...

introduction: although, the effect of direct intra-articular injection of bone marrow stem cells (bmscs) on the repair of articular cartilage and the effect of elaeagnus angustifolia extract on pain relief in patients with osteoarthritis have been investigated, no studies has been conducted to compare the effects of these two therapeutic methods on the mechanical properties of articular cartila...

An investigation has been carried out into the microstructures developed during the early stages of equal channel angular extrusion (ECAE) in a polycrystalline single-phase Al-0.13Mg alloy, with emphasis on the substructural alignment with respect to the die geometry and the crystallographic slip systems, which is essentially related to the grain refinement and texture development during deform...

It has been shown experimentally that the load carrying capacity of the spine significantly increases when compressive loads are carried along the follower load (FL) direction. However, it is necessary to modify the current FL concept because a certain amount of shear force is produced during activities in daily life. In this study, a clinically allowable range of shear force was investigated u...

In a Z-core sandwich panel, the shear stiffness of the sandwich panel in the weak direction which is perpendicular to the placement of the Z-cores is much smaller than the bending stiffness because the hollow section between the two facing plates cannot sustain shear action. Because of this fact, the shear deformation of a Z-core sandwich panel under bending in the weak direction cannot be igno...

UNLABELLED Gap-dependent total knee arthroplasty involves applying a tension force to open the joint space. Intuitively, this force is dependent on the degree of joint deformity. AIM The study aims at determining the amount of force and its influence on morphological parameters. MATERIAL AND METHODS In a group of 70 patients in whom total knee arthroplasty was performed ligament tension for...

In this paper, the drawing process of multi-layer sheet metal through wedge shaped die has been analyzed using stream function and upper bound method. Typically a sandwich sheet contains three layers of metal, where the outer layers are of the same thickness and material and different from those of the inner layer. In this study, a new deformation model has been introduced in which inlet and ou...

Haemodynamic forces applied at the apical surface of vascular endothelial cells (ECs) provide the mechanical signals at intracellular organelles and through the inter-connected cellular network. The objective of this study is to quantify the intracellular and intercellular stresses in a confluent vascular EC monolayer. A novel three-dimensional, multiscale and multicomponent model of focally ad...

Whole cell and membrane deformability are essential for red blood cell (RBC) survival and for effective blood flow. Neonatal RBCs display several specific properties (eg, large size, high hemoglobin F) that could influence their deformation characteristics and contribute to their shortened life span. The present study was designed to compare selected rheologic properties (cellular deformability...