Platelets exposed to shear stress aggregate in the absence of exogenously added agonists, utilizing distinct platelet membrane receptors and ligands depending upon the level of shear stress applied. Using a modified cone and plate type viscometer, we previously demonstrated that, under low shear stress (18 dyn/cm2), aggregation is mediated by platelet membrane glycoprotein (GP) IIb-IIIa and fib...

Extensive computer experiments have been conducted in order to shed light on the macroscopic shear flow behavior of liquid n-hexadecane fluid under isobaric-isothermal conditions through the nonequilibrium molecular dynamic methodology. With respect to shear rates, the accompanying variations in structural properties of the fluid span the microscopic range of understanding from the intrinsic to...

In this paper, a two-dimensional (2D) quantitative sonoelastographic technique for estimating local shear wave speeds from slowly propagating shear wave interference patterns (termed crawling waves) is presented. Homogeneous tissuemimicking phantom results demonstrate the ability of quantitative sonoelastographic imaging to accurately reconstruct the true underlying shear wave speed distributio...

Flow and transport are studied in transparent model fractures with rough complementary self-affine walls with a relative shear displacement ~u. The aperture field is shown to display long range correlations perpendicular to ~u: for flow in that direction, the width and geometry of the front of a dyed shear-thinning polymer solution displacing a transparent one have been studied as a function of...

Radial glial cells (RGCs) which function as neural stem cells are known to be non-excitable and their proliferation depends on the intracellular calcium (Ca2+) level. It has been well established that Inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release and Ca2+ entry through various Ca2+ channels are involved in the proliferation of RGCs. Furthermore, RGCs line the ventricular wall and are...

Synchrotron radiation imaging with refraction enhancement was successfully applied to image air voids in opaque plastic materials, which otherwise could hardly be depicted(1). It was suggested that this imaging technique had a superior performance in nondestructive testing of small voids in plastics(1). It has been recognised in previous works that the edge enhancement effect due to X-ray refra...

Platelet functions are increasingly measured under flow conditions to account for blood hydrodynamic effects. Typically, these studies involve exposing platelets to high shear stress for periods significantly longer than would occur in vivo. In the current study, we demonstrate that the platelet response to high shear depends on the duration of shear exposure. In response to a 100 dyn/cm2 shear...