5-Aza-2'-deoxycytidine which is preferentially taken up by the lymphatic tissue and is incorporated into DNA strongly affects the ability of the immune system to synthesize IgG antibodies against sheep red blood cells without affecting IgM antibody formation. A single dose of the drug results in a prolonged inhibition persisting 14 days after the secondary immunization. The inhibitory effect is...

1. At a temperature of 1 degrees C., C'2, C'4, and C'1 combine with sensitized sheep erythrocytes, while C'3 does not combine. 2. C'1, although combining with sensitized cells in the absence of C'4, is hemolytically inert unless C'4 combines previous to, or simultaneously with it. 3. C'4 does not combine in the absence of C'1. 4. Although C'3 is not fixed by antibody-sheep cell aggregates, it i...

habitat associations of wild sheep, alborz red sheep (ovis orientalis gemelini x ovis orientalis arkali ), in khojir and sorkheh hesar national parks were studied over three seasons (spring, autumn and winter) in 2000. the position of observed maternal groups (including ewe with lamb) and male groups (including rams, barren ewes and juveniles) were determined on topographical maps during the fi...

This study aimed to assess the effect of percutaneous transthoracic lung biopsy on the oxidative metabolism of sheep by measuring the oxidative stress markers of superoxide dismutase (SOD), total glutathione (GSH-t), peroxidase (GSH-Px) and thiobarbituric acid reactive substances (TBARS) in the red cells of these animals. Blood samples were collected from 20 clinically healthy sheep prior t...

Susceptibility of sheep erythrocytes to Babesia divergens was investigated in vitro and a high inter-individual variability in their ability to support parasite population development was demonstrated, with some individuals having refractory red blood cells (RBC). As neither changes in growth conditions nor the use of different B. divergens strains influenced the level of susceptibility, the ma...

A method for the primary stimulation and measurement of antibody production to sheep red blood cells in vitro has been described. In this system when mouse spleen cells are incubated with sheep erythrocytes large complement-dependent plaques are formed. The number and size of plaques increases from day 1 to day 3 of incubation with an average of 4.4 plaque areas per 1 x 10(6) cells plated at da...

The research was conducted to study the effect of heat stress on blood parameters in indigenous sheep. Nine sheep were divided into three groups which were almost similar in age, sex and weight. Three groups were divided as zero hour (T0), four hours (T4) and eight hours (T8) heat exposure to direct sunlight. During experimental period temperature–humidity index (THI) value was calculated as 27...

The histological study was carried out on mammary glands collected from 14 Madras red sheep, 7 in lactating period 7 in non-lactation period. The connective tissue became reduced and lobuloalveolar tissue was predominantly increased during lactating period. The alveoli were laminated, filled with secretion and lined by cuboidal active secretory cells containing lipid droplets and protein granul...

Louping-ill (LI) is a tick-borne viral disease of red grouse, Lagopus lagopus scoticus Lath. (Tetraonidae: Galliformes), and sheep, Ovis aries L. (Bovidae: Artiodactyla), that causes economic loss to upland farms and sporting estates. Unvaccinated sheep, grouse and mountain hares, Lepus timidus L. (Leporidae: Lagomorpha), are known to transmit LI virus, whereas red deer, Cenrus elaphus L. (Cerv...

This study evaluated the subchronic toxicity of selected halomethanes which are drinking water contaminants. The compounds studied were trichloromethane, bromodichloromethane, dibromochloromethane and tribromomethane. Subchronic 14-day gavage studies were performed with the use of doses encompassing one-tenth the LD50 for the compounds. A 90-day gavage study of one of the compounds, trichlorome...