We analyzed a BHK cell line persistently infected with Sindbis virus for 16 months and a virus (Sin-16) cloned from these cells. Sin-16 virus was resistant to the defective interfering particles present in the original infection. We found that (i) cells infected with Sin-16 were impaired in the processing of a viral precursor glycoprotein, (ii) high-multiplicity passaging of Sin-16 gave rise to...

The new curve contains all of the information about the original curve’s tangent lines. For example, it crosses the y-axis whenever the original curve has a horizontal tangent line. The straight line y = mx + b, or (x(t), y(t)) = (t,mt + b), has only one tangent line and thus a trivial transformation to a point, (x∗(t), y∗(t)) = (m, b). Some conic sections transform to conic sections. For examp...

The mode of action of the active metabolite SIN-I of the vasodilator prodrug molsidomine was studied in vitro and in vivo in corpus cavernosum of rabbit and man. SIN-I produces a dose-dependent relaxation of isolated human cavernous smooth muscle strips. In the rabbit, the intracavernous application of SIN-I increased the intracavernous pressure to a full erection (approximately 100 cm H2O). Th...

— The nature of point defects in nematic liquid crystals has been studied by placing droplets on a water substrate and viewing these between crossed polarizers. Three configurations are observed. These configurations are accounted for by minimizing the Frank elastic energies with suitable boundary conditions. The second order nonlinear simultaneous partial differential equations that describe s...

The mechanisms that regulate cytoskeletal remodeling during the transition between mitosis and interphase are poorly understood. In fission yeast the MOR pathway promotes actin polarization to cell tips in interphase, whereas the SIN signaling pathway drives actomyosin ring assembly and cytokinesis. We show that the SIN inhibits MOR signaling in mitosis by interfering with Nak1 kinase-mediated ...

The effects of sputtered SiN on current collapse of AlGaN/GaN HEMTs have been studied. The current collapse in terms of dynamic on-state resistance was reduced with increasing SiN deposition and post annealing temperatures due to the reduction of SiN/AlGaN interface trap density. These results indicate that sputtered SiN with deposition temperature at 250 °C is a promising candidate for passiva...

Sepsis, a systemic inflammatory response to infection, is the major cause of death in intensive care units (ICUs). The mortality rate of sepsis remains high even though the treatment and understanding of sepsis both continue to improve. Sinomenine (SIN) is a natural alkaloid extracted from Chinese medicinal plant Sinomenium acutum, and its hydrochloride salt (Sinomenine hydrochloride, SIN-HCl) ...

It is an experimental fact that atmospheric, solar, reactor and accelerator neutrinos change flavour. The present data [1] give the solar lepton mixing angle sin θ12 = 0.32 with a relative error about of 25%(@3σ), the atmospheric angle sin θ23 = 0.5 with a relative error about of 34%(@3σ) and sin θ13 ≤ 0.05(@3σ). The complex phase has not been measured. Precise future data might confirm the max...

PURPOSE To investigate the development of intimal hyperplasia in response to percutaneous transluminal coronary angioplasty (PTCA) followed by local delivery of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1). MATERIAL AND METHODS Overdilation PTCA was performed in coronary arteries in 20 healthy pigs. One of the dilated segments was additionally treated with local delivery of SI...

background and aim : the quick speech in noise (q-sin) test have been designed to evalu­ate individuals’ ability to recognize speech in noise. this study established to evaluate the test-retest reliability and equivalency of the five test lists of the persian q-sin test in subjects with sensory hearing loss (shl) and normal hearing individuals. methods : this cross-sectional study was per­forme...