OBJECTIVE Drug resistant focal epilepsy can be treated by resecting the epileptic focus requiring a precise focus localisation using stereoelectroencephalography (SEEG) probes. As commercial SEEG probes offer only a limited spatial resolution, probes of higher channel count and design freedom enabling the incorporation of macro and microelectrodes would help increasing spatial resolution and th...

introduction: nucleus reticularis paragigantocellularis (pgi) is one of the major components of the rostral ventromedial medulla (rvm), which is involved in nociceptive processing and pain modulation. the aim of this study was to examine the effect of c fiber destruction on responsiveness of nucleus reticularis paragigantocellularis (pgi) to formalin, as a noxious stimulus, in normal and morphi...

SCHWARTZ, E. L., A. RAMOS AND E. R. JOHN. Single cell activity in chronic unit recording: o quantitative study of the unit amplitude spectrum. BRAIN RES. BULL. l(1) 57-68, 1976. The ratio of standard deviation to mean, of the amplitude spectrum of well resolved single units, is shown to scale exponentially. This scaling is explained on the basis of a consideration of the relationship of extrace...

Koyano KW, Machino A, Takeda M, Matsui T, Fujimichi R, Ohashi Y, Miyashita Y. In vivo visualization of single-unit recording sites using MRI-detectable elgiloy deposit marking. J Neurophysiol 105: 1380–1392, 2011. First published December 1, 2010; doi:10.1152/jn.00358.2010.— Precise localization of single-neuron activity has elucidated functional architectures of the primate cerebral cortex, re...

The success of long-term electrophysiological recordings often depends on the quality of the implantation surgery. Here we provide useful information for surgeons who are learning the process of implanting electrode systems. We demonstrate the implantation procedure of both a penetrating and a surface electrode. The surgical process is described from start to finish, including detailed descr...

RECENT SINGLE-UNIT recording studies of the alert rhesus monkey superior colliculus have disclosed that the deeper layers of this structure contain cells which discharge in association with eye movement (15-17, 23, 24). Such units fire selectively prior to saccades of a specific direction and size, irrespective of the position of the eye in orbit. Stimulation studies of the superior colliculus ...

For recording the activity of single neurons in unanesthetized animals two techniques can be used: permanently implanted microwires (7) or movable microelectrodes (1, 2, 4-6, 8). The latter method permits to make a selection of cells in the course of the experiment. However, cells cannot be kept for a long time and are easily lost during violent head movements. Besides, successive penetrations ...

The glycogen-depletion technique has become a well-established method for determining histologically the cross-sectional distribution of a single muscle unit. A major drawback of this method is its low yield of one depleted unit per experiment. Furthermore, this technique is particularly unsuited for determining the longitudinal distribution of single muscle units in long, broad muscles because...

A method is described by which a single shaft multiwire microelectrode can be fabricated efficiently. The resulting electrode can be attached to a commercial microdrive and used for single neuronal unit recording from one or more tracks in deep brain structures of anesthetized or awake animals. The electrode consists of a 30 gauge stainless steel cannula through which multiple strands of 13 mic...