نتایج جستجو برای: sirtuin 1
تعداد نتایج: 2753772 فیلتر نتایج به سال:
amino-group of lysines is an important switch in gene regulation and protein activity and has gained increasing interest in molecular biology and drug discovery in the last decade. One of the enzyme families that catalyze the cleavage of an acetyl group are the NAD+-dependent protein deacetylases, the sirtuins. The human sirtuins have seven members, Sirt1-7. Even though the biology of the sirtu...
Introduction: Sirtuin 1 is a protein deacetylase that plays an important role in many cellular processes. The serum sirtuin 1 levels are higher in the polycystic ovary syndrome (PCOS) patients than the healthy subjects. The aim of this study was to assess the role of SIRT-1 rs7895833 polymorphism in the susceptibility of PCOS. Methods: This case-control study was done on 456 Iranian women fr...
OBJECTIVE Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1 gene. Patients with MFS are at risk of aortic aneurysm formation and dissection. Usually, blood pressure-lowering drugs are used to reduce aortic events; however, this is not sufficient for most patients. In the aorta of smooth muscle cell-specific sirtuin-1-deficient mice, spontaneous aneurys...
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