Brief, localized, cutaneous, non-painful thermal stimuli can evoke a transient vasomotor response, causing increased cutaneous blood flow and elevated skin temperature. The aims of this study were to investigate 1) if cutaneous sensitization by topical application of capsaicin (TRPV1 receptor agonist) can facilitate the size, duration and spatial extent of this vasomotor response and 2) if male...

Current Opinion in Allergy and Clinical Immunology 2008, 8:115–119 Purpose of review Exposure to occupational and environmental agents can cause a spectrum of lung diseases that are predominantly immune-mediated. Research and prevention have focused primarily on the respiratory tract. Recent studies, however, suggest that the skin may also be an important route of exposure and site of sensitiza...

patients and methods in this cross sectional study, 295 volunteers with the signs and symptoms of allergic diseases who referred to the khuzestan jahad daneshgahi medical center in ahvaz during 2010 were investigated. all patients were subjected to skin prick test (spt) with common allergenic extracts. data were analyzed by spss-18 software using chi square test. results seventy subjects, compr...

The induction by chemicals of allergic sensitization and allergic disease is an important and challenging branch of toxicology. Skin sensitization resulting in allergic contact dermatitis represents the most common manifestation of immunotoxicity in humans, and many hundreds of chemicals have been implicated as skin sensitizers. There are far fewer chemicals that have been shown to cause sensit...

In order to compare delayed-type hypersensitivity (DTH) among different exposure sites, we evaluated the sensitization potency of mercuric chloride (HgCl(2)) via exposure to the skin, or oral or esophageal mucosa using the mouse ear swelling test. Furthermore, we investigated in vitro splenocyte proliferation reaction and cytokine profile in HgCl(2)-exposed and control mice. Sensitization with ...

151 Allergic contact dermatitis (ACD) is the clinical condition resulting from skin sensitization, which is a delayed-type hypersensitivity reaction induced by small reactive chemicals (haptens). to ensure that ingredients in cosmetic products do not induce skin sensitization (and hence do not cause ACD in consumers), a risk assessment is performed to evaluate the risk to humans and to substant...

PURPOSE Sensitization to specific allergens may be important in the development of allergic airway inflammation and airway hyperresponsiveness (AHR). We evaluated the effect of specific aeroallergen sensitization on eosinophilic airway inflammation and AHR. METHODS We reviewed retrospectively the clinical data of subjects who underwent skin prick tests to aeroallergens, induced sputum analysi...

BACKGROUND It hasn't been clearly understood yet whether sensitization to antibiotics, the virus itself or transient loss of drug tolerance due to the virus, is responsible for the development of maculopapular exanthems following amoxicillin intake in patients with infectious mononucleosis. We aimed to examine whether sensitization to penicillin developed among patients with skin rash following...

BACKGROUND Profilin is a panallergen found in pollens and fruits. Sensitization to this protein may explain some sensitization to multiple pollen species. We aimed to evaluate sensitization to profilin in patients suffering from respiratory allergy sensitized to pollens, in the Central region of Portugal. METHODS Patients were evaluated for asthma symptoms, rhinitis, conjunctivitis and food a...

Abnormal processing of somatosensory inputs in the central nervous system (central sensitization) is the mechanism accounting for the enhanced pain sensitivity in the skin surrounding tissue injury (secondary hyperalgesia). Secondary hyperalgesia shares clinical characteristics with neurogenic hyperalgesia in patients with neuropathic pain. Abnormal brain responses to somatosensory stimuli have...