Uptake of chloroform into hairless rat stratum corneum from dilute aqueous solutions was studied using tape-stripping to determine amounts deposited in the skin under various environmental exposure scenarios. The length of exposure of sedated animals to the chloroform-containing medium, the frequency and duration of tape-stripping, and the number of tape-strips per location were varied to map t...

OBJECTIVE To examine the effect of a brief laboratory stressor and social support before the stressor on cardiovascular and cortisol responses, and skin barrier recovery after skin disruption. METHODS Eighty-five healthy participants (mean age 22.9 +/- 4.4 years) underwent a "tape-stripping" procedure that disrupts normal skin barrier function, and were randomly assigned to a No Stress (readi...

In topical administration of antifungals, the drugs should pass the stratum corneum to reach lower layers of the skin in effective concentrations. Thus, the formulation of antifungal agents into a suitable delivery system is important for the topical treatment of fungal infections. Nanosized colloidal carriers have gained great interest during the recent years to serve as efficient promoters of...

For most xenobiotics, the rates of percutaneous absorption are limited by diffusion through the horny layer of skin. However, percutaneous absorption of chemicals may seriously increase when the skin is damaged. The aim of this work was to develop an in vitro representative model of mechanically damaged skins. The epidermal barrier was examined following exposure to a razor, a rotating brush, a...

Psoriasis is characterized by hyperproliferation of keratinocytes and by infiltration of activated Th1 and Th17 cells in the (epi)dermis. By expression microarray, we previously found the GATA3 transcription factor significantly downregulated in lesional psoriatic skin. Since GATA3 serves as a key switch in both epidermal and T helper cell differentiation, we investigated its function in psoria...

Peristomal skin complications are the most common reason ostomy patients visit an outpatient wound, ostomy, and continence nursing service. Prevention and management of peristomal skin complications are critical components of ostomy care. Identifying risk factors for the occurrence of peristomal skin complications according to types of injury and clinical features can help optimize assessment a...

In the present study, the effect of successive milt collection was investigated on spermatological parameters and reproduction successes of wild and cultured endangered caspian brown trout. The milt collection was done 3 times with two weeks intervals. After milt collection, amount of milt was allocated for milt quality evaluation and reminders used for fertilization. According to results, in w...

Sequential injection system (SI system) was used for the pretreatment of a carbon electrode in an anodic stripping voltammetry (ASV) for the determination of arsenic (III). In this research, a screen-printed carbon electrode (SPCE) was used; SPCE was prepared in our laboratory by us. In ASV, SPCE was chosen as a working electrode because SPCE is less expensive, easy to use for a flow cell and s...

Atopic dermatitis (AD) is a common allergic inflammatory skin disease caused by a combination of intense pruritus, scratching, and epicutaneous (e.c.) sensitization with allergens. To explore the roles of IL-21 and IL-21 receptor (IL-21R) in AD, we examined skin lesions from patients with AD and used a mouse model of allergic skin inflammation. IL-21 and IL-21R expression was upregulated in acu...