•Lichen sclerosus in females primarily involves the hairless anogenital skin.•Skin tissue outside this area is constitutionally not at risk for lichen sclerosus.•Transplantation into the vulvar field may turn skin susceptible to lichen sclerosus.•Tissue inherent positional information might affect lichen sclerosus susceptibility.

BACKGROUND Immunosuppression for solid organ transplantation is associated with increased incidence of internal and cutaneous malignant tumors, among which skin cancer is the most common. OBJECTIVE To determine the effects on cutaneous carcinogenesis when stopping therapy with immunosuppressive medications. OBSERVATIONS We followed the clinical course of 6 solid organ transplant recipients ...

BACKGROUND Recent studies have shown that skin flap transplantation technique plays an important role in surgical procedures. However, there are many problems in the process of skin flap transplantation surgeries, especially ischemia-reperfusion injury, which directly affects the survival rate of the skin flap and patient prognosis after surgeries. MATERIAL AND METHODS In this study, we used a ...

Cluster of differentiation (CD)147 is highly involved in the T cell activation process. High CD147 expression is observed on the surfaces of activated T cells, particularly CD4+ T cells. In organ transplantation, it is important to prevent graft rejection resulting from the excessive activation of T cells, particularly CD4+ T cells, which exhibit a key role in amplifying the immune response. Th...

Skin engineering provides a new strategy for treating a wide variety of skin defects. In particular, electrospun nanofibrous membranes have been used as carriers for epidermis engineering. The aim of this study was to investigate the feasibility of a modified gelatin and polycaprolactone (GT/PCL) electrospun membrane for epidermis engineering. The biocompatibility of the membranes was evaluated...

INTRODUCTION Several skin disorders, immunosuppression-induced, have been described in transplant recipients. The aim of our study is to characterize the clinical spectrum of skin disorders and to compare the findings in liver and kidney transplant recipients. MATERIAL AND METHODS A retrospective descriptive study was conducted. Data were collected from the medical records of all liver and ki...

A 46 year old male with first liver transplantation and second kidney transplantation on the 4th March 2001 with HCV and HBV positive serology, developed back and abdominal pain, weight loss and weakness in August 2001. Physical examination revealed poor general status, pleural effusion, hepatosplenomegaly, ascitis and a 5 mm red nodular lesion in the abdominal skin. Immunosuppressive regimen w...

A highly significant, but unanswered, question in the pathogenesis of psoriasis relates to how normal appearing and diseased skin can coexist, undergo spontaneous flares and remissions, and yet appear to be genetically acquired. A plausible explanation for these disparate observations is that there is a basic defect in epidermal proliferation of skin of subjects with psoriasis and that disease ...