نتایج جستجو برای: slc30a8
تعداد نتایج: 228 فیلتر نتایج به سال:
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion
of a Zinc Transporter (SLC30A8) Variant A 14-Cohort Meta-Analysis Stavroula Kanoni, Jennifer A. Nettleton, Marie-France Hivert, Zheng Ye, Frank J.A. van Rooij, Dmitry Shungin, Emily Sonestedt, Julius S. Ngwa, Mary K. Wojczynski, Rozenn N. Lemaitre, Stefan Gustafsson, Jennifer S. Anderson, Toshiko Tanaka, George Hindy, Georgia Saylor, Frida Renstrom, Amanda J. Bennett, Cornelia M. van Duijn, Jos...
The genomes of many species have now been completely sequenced including human and mouse. Great progress has been made in understanding the complex genetics that underlie diabetes and obesity in human populations. One of the current challenges is the functional identification and characterization of the genes within loci that are being mapped. There are many approaches to this problem and this ...
Zinc deficiency is a risk factor for obesity and diabetes. However, until recently, the underlying molecular mechanisms remained unclear. The breakthrough discovery that the common polymorphism in zinc transporter SLC30A8/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes. Our group and others showed that altered ZnT8 function may be in...
BACKGROUND Obesity and type 2 diabetes mellitus (T2D) are known risk factors for colon cancer. Recent reports from a number of genome wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with obesity and T2D. Here we tested the hypothesis that these SNPs may also be associated with risk of colon cancer. METHODS We genotyped nine SNPs report...
Using RNA sequencing of triple-negative breast cancer (TNBC), non-TBNC and HER2-positive breast cancer sub-types, here we report novel expressed variants, allelic prevalence and abundance, and coexpression with other variation, and splicing signatures. To reveal the most prevalent variant alleles, we overlaid our findings with cancer- and population-based datasets and validated a subset of nove...
d Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, USA. *Correspondence to: Dr. Liegang Liu, Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, W...
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