We fit a Markov chain model of microsatellite evolution introduced by Kruglyak et al. to data on all di-, tri-, and tetranucleotide repeats in the yeast genome. Our results suggest that many features of the distribution of abundance and length of microsatellites can be explained by this simple model, which incorporates a competition between slippage events and base pair substitutions, with no n...

Replication slippage or slipped-strand mispairing involves the misalignment of DNA strands during the replication of repeated DNA sequences, and can lead to genetic rearrangements such as microsatellite instability. Here, we show that PolB and PolD replicative DNA polymerases from the archaeal model Pyrococcus abyssi (Pab) slip in vitro during replication of a single-stranded DNA template carry...

We present a case of acute gastric band slippage with gastric necrosis and massive haemoperitoneum necessitating an emergency surgery. The patient presented with an 8h history of dysphagia, vomiting and epigastric pain. Initial examination was unremarkable, but within 6h the patient suddenly deteriorated with a distended peritonitic abdomen. At laparotomy the patient was found to have gastric b...

The purpose of this work is to investigate the accurate trajectory tracking control of a wheeled mobile robot (WMR) based on the slip model prediction. Generally, a nonholonomic WMR may increase the slippage risk, when traveling on outdoor unstructured terrain (such as longitudinal and lateral slippage of wheels). In order to control a WMR stably and accurately under the effect of slippage, an ...

We report the first numerical demonstration of the generation of multiple superradiance pulses in a slippage-dominant freeelectron laser amplifier. In this simulation, the 1 and 2 multiple radiation-pulses are created from the deformation of the longitudinal phase space. Our simulation confirmed controllability over the temporal profile of these pulses, and paves the way for applying this techn...

This paper presents the measured energy losses in a draw gear with NE22, XH500, LL2, and CFG flat belts. The ranges of torque capacity, slippage occurrence, transmission efficiency selected drive belts are also presented. Knowing exact values these parameters allows selection most suitable for different applications. In addition, belt manufacturers do not provide data accurately, leading to mac...

Introduction: Slippage is usually measured with a standard manual method, however, if it required slippage information inline in extensive areas of cropland, mechanical and electronic equipment have to be developed. Objective: To design, assemble evaluate (in laboratory under field conditions) an encoder-based measurement system. Methodology: The system was integrated tested the laboratory, whe...

We report the first experimental demonstration of a slippagedominant superradiant free-electron laser (FEL) using an ultrafast seed-laser pulse. We measured the evolution of the longitudinal phase space in the slippage-dominant superradiant regime. With a roughly 1% variation in the electron beam energy, we observed a seed-like fully longitudinal coherence, and a 2% wavelength shift from the se...

We consider the problems of kinematic and dynamic constraints, with actuator saturation and wheel slippage avoidance, for motion planning of a holonomic three-wheeled omni-directional robot. That is, the motion planner must not demand more velocity and acceleration at each time instant than the robot can provide. A new coupled non-linear dynamics model is derived. The novel concepts of Velocity...

Hydrophobic coatings, such as octadecyltrichlorosilane or n-alkyl monolayers, enhance the slippage of liquids on solid walls. For a given alkyl chain length, the main structural parameter for homogeneous coatings is the tilt angle between coating molecules and the surface normal. In this paper, ab initio calculations are used to calculate the equilibrium configuration of coating molecules, show...