Background ANDHI was done to assess the efficacy of benralizumab, including onset effect and impact on health-related quality life (HRQOL), exacerbation rate, lung function, nasal polyposis symptoms. Methods This phase 3b, randomised, double-blind, parallel-group, placebo-controlled study completed in adults (aged 18–75 years) with severe eosinophilic asthma at least 2 exacerbations previous ye...

Introduction. Chronic rhinosinusitis is a highly prevalent disease, so it is necessary to create valid instruments to assess the quality of life of these patients. The SNOT-20 questionnaire was developed for this purpose as a specific test to evaluate the quality of life related to chronic rhinosinusitis. It was validated in the English language, and it has been used in most studies on this sub...

BACKGROUND Episodic or recurrent sinonasal symptoms are often suspected as "sinus" in origin. With normal sinus radiology between events, the diagnosis of recurrent acute rhinosinusitis (RecARS) is made. However, other conditions can produce episodic symptoms. In this study we analyze acutely performed computed tomography (CT) in a population with suspected or self-diagnosed "sinus" disease. ...


 CADTH recommends that Nucala should be reimbursed by public drug plans for the treatment of patients with severe chronic rhinosinusitis nasal polyps (CRSwNP) if certain conditions are met.
 only covered to treat adult CRSwNP who have on both sides nose, already had at least 1 surgery their or cannot this type surgery, and still symptoms despite corticosteroid 3 months. When is first...

OBJECTIVE This study was designed to determine whether smoking patients have poorer outcomes after endoscopic sinus surgery (ESS) based on a reliable validated rhinosinusitis-specific quality-of-life outcomes test. STUDY DESIGN Retrospective chart and computed tomography (CT) review with telephone and letter questionnaire. METHODS Charts of 230 adult patients undergoing ESS for chronic rhin...