1. Distal blockade by simultaneous administration of ethacrynic acid and chlorothiazide was performed in healthy subjects whose extracellular fluid was expanded by iso-osmotic sodium chloride or bicarbonate. The results obtained were compared with those from non-expanded subjects (Ardaillou & Fillastre, 1969). 2. By this technique urine approximates in composition to proximal tubular fluid and ...

D(5) dopamine receptor (D(5)R)-deficient (D(5)(-/-)) mice have hypertension that is aggravated by an increase in sodium intake. The present experiments were designed to test the hypothesis that a dysregulation of renal sodium transporters is related to the salt sensitivity in D(5)(-/-) mice. D(5)R was expressed in the renal proximal tubule, thick ascending limb, distal convoluted tubule, and co...

Azimov R, Abuladze N, Sassani P, Newman D, Kao L, Liu W, Orozco N, Ruchala P, Pushkin A, Kurtz I. G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis. Am J Physiol Renal Physiol 295: F633–F641, 2008. First published July 9, 2008; doi:10.1152/ajprenal.00015.2008.— Autosomal recessive proximal renal tubular acidosis is caused by ...

background: sodium bicarbonate serum therapy is used for compensation bicarbonate lost and increasing blood ph in metabolic acidosis caused by severe anemia in patient with glucose-6-phosphate dehydrogenase (g6pd) deficiency. the aim of present study was comparison the effect of serum therapy using two different serums (serum with bicarbonate and without bicarbonate) on some renal and hematolog...

Subclinical left ventricular (LV) dysfunction is highly prevalent in people with type 2 diabetes mellitus (T2DM) and independently associated poor cardiovascular outcome ([1][1]). Sodium-glucose cotransporter inhibitors (SGLT2i) have been shown to reduce hospitalizations for heart failure

1. The correction of metabolic acidosis with sodium bicarbonate remains controversial. Experiments in vitro have suggested possible deleterious effects after alkalinization of the extracellular fluid. Disequilibrium of carbon dioxide and bicarbonate across cell membranes after alkali administration, leading to the phenomenon of 'paradoxical' intracellular acidosis, has been held responsible for...

The purpose of this study was to evaluate the effect of oral administration of sodium bicarbonate (300 mg·kg(-1) b.w.) on swim performance in competitive, (training experience of 6.6 ± 0.6 years) youth, (15.1 ± 0.6 years) male swimmers. The subjects completed a test trial, in a double blind fashion, on separate days, consisting of 4 x 50m front crawl swims with a 1(st) minute passive rest inter...