نتایج جستجو برای: sodium bisulfate
تعداد نتایج: 187788 فیلتر نتایج به سال:
Background: Addiction is a polygenic disorder caused by genetic and environmental factors. The opioid material can act as an epigenetic element, like DNA methylation. The present study aimed to examine the effect of epigenetic drugs such as nicotine, morphine, methadone, and buprenorphine on the methylation of two CpG sites in promoter of Oprm1 gene in male Wistar rats. Materials & Methods: In...
BACKGROUND AND AIMS The nephrotoxic mechanisms of andrographolide sodium bisulfate (ASB) remain largely unknown. This study attempted to explore the mechanism of ASB-induced nephrotoxicity using human proximal tubular endothelial cells (HK-2). METHODS For this study HK-2 cells were treated with rising concentrations of ASB. Their survival rate was detected using MTT assay and ultrastructure w...
OBJECTIVES This study was undertaken to investigate the protective effects of vitamin B6, cofactor for cystathionine-γ lyase and cystathionine-β synthase (producers of H2S), alone and in combination with L-cysteine, H2S precursor, on indomethacin-, and ethanol-induced gastric lesions in male NMRI mice. MATERIALS AND METHODS Fasted male NMRI mice were randomly assigned into 12 groups (7 in eac...
On December 6, 2011, the Federal Court of Canada issued its decision1 in the well-known dispute between Apotex Inc. and Sanofi-Aventis over the anticoagulant drug, clopidogrel bisulfate, sold in Canada under the brand name Plavix. This compound is a single enantiomer of a previously disclosed racemate. The Court invalidated Sanofi’s patent (Canadian patent no. 1,366,777, “the ′777 Patent”). An ...
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