Central haemodynamics and regional blood flow were investigated during and after sodium nitroprusside (SNP) infusion in halothane anaesthetized rats. The administration of SNP 40 micrograms kg-1 min-1, decreased mean arterial pressure (MAP) to 52 (mean) mm Hg. Cardiac output (CO) remained unchanged, while heart rate (HR) and systemic vascular resistance (SVR) decreased. The regional blood flow ...

introduction: during the recent years many studies have been performed on the effects of nitric oxide andoxygen-derived free radicals (ofr) on the aorta, but there is no report on the effects of simultaneousmanipulation of both systems on the relaxation of this artery. material and methods: after anaesthesia, aortic rings from male rats (320-420 g) were obtained. thepieces of aorta were mounted...

Curcumin, a polyphenolic compound extracted from Curcuma longa, has several pharmacological activities such as anticancer, anti-inflammatory, and antioxidant effects. The purpose of this study was to investigate the protective effects of curcumin and THERACURMIN, a highly bioavailable curcumin, against sodium nitroprusside (SNP)-induced oxidative damage in primary striatal cell culture. THERACU...

Nitric oxide (NO) is a bioactive and a multifunctional gaseous molecule signal playing a central role and mediating variety of physiological processes in plants. In this study, the protective effect against chilling stress of exogenously applied sodium nitroprusside (SNP, a NO donor) in Cucumis sativus L. cv ZND407 and cv ZND461 was investigated. The SNP was sprayed over cucumber seedlings usin...

Abstract The protective mechanism of nitric oxide (NO) in regulating tolerance to Cu-induced toxicity shoots barley ( Hordeum vulgare L.) was studied. experiment consisted four treatments based on additions basal nutrient solutions (BNS): control (CTR), Cu (200 µM), SNP (500 and µM) + over a period 10 days. Treatment with significantly reduced seedling growth photosynthetic efficiency concomita...

We have examined the cerebrovascular response to carbon dioxide during normotension, sodium nitroprusside (SNP)-induced hypotension and high dose isoflurane-induced hypotension in 10 patients who received a standardized general anaesthetic. Carbon dioxide reactivity was determined by varying PaCO2 between 3.0 and 8.0 kPa and recording simultaneously blood flow velocity from the middle cerebral ...

Sodium nitroprusside (SNP) is an anti-hypertensive drug, commonly used to decrease the systemic vascular resistance and lower the blood pressure. When the amount of cyanide generated by the SNP exceeds the metabolic capacity for detoxification, cyanide toxicity occurs. Under general anesthesia and cardiopulmonary bypass (CPB), it may be difficult to detect the development of cyanide toxicity. I...

PURPOSE In the rabbit iris sphincter muscle, sodium nitroprusside (SNP), a nitric oxide (NO) donor, inhibits cholinergic contraction but does not affect tachykinergic contraction in vitro. The objectives of the current study were to clarify the mechanism for the different responsiveness to NO in cholinergic and tachykinergic muscular contractions, and to examine whether the mechanism for NO-ind...

Novel double-shelled hierarchical ferrihydrite hollow spheres (Fe(10)O(14)(OH)(2).4H(2)O) were successfully synthesized on a large scale by using a facile medicine-inspired solution-phase approach. Sodium nitroprusside (SNP), an ordinary and inexpensive medicine for expanding blood vessels, served as both a ferric source and an in situ formed gas-bubble template with the presence of sodium dihy...

Sir,—An otherwise excellent and thorough report by Vesey, Cole and Simpson (1976) fails to acknowledge or refute a hypothesis which has already appeared in this Journal (Smith and Kruszyna, 1976a) about the mechanism by which cyanide is released from nitroprusside in vivo, and the significance of that reaction for blood cyanide concentrations. We are delighted with the confirmation that "The re...