Cataract, the opacification of eye lens, is the leading cause of blindness worldwide. At present, the only remedy is surgical removal of the cataractous lens and substitution with a lens made of synthetic polymers. However, besides significant costs of operation and possible complications, an artificial lens just does not have the overall optical qualities of a normal one. Hence it remains a si...

The need to explore new alternative therapeutic strategies and chemoprevention methods for hepatocellular carcinoma is growing significantly. Selenium is a trace element that plays a critical role in physiological processes, and is used in cancer chemoprevention. The aim of this work was to test in vitro the effect of sodium selenite on the human hepatoma cell lines, HepG2 and Huh7, to assess i...

Effects of Sodium Selenite on Methylmercury Embryotoxicity and Teratogenicity in Mice. NOBUl'AGA, T., SATOH, H., AND SUZUKI, T. (1979). Toxicol. Appl. Pharmacal. 47, 79-88. Female IVCS mice were fed food containing methylmercury (MeHg) at 0, 15.9, or 31.9 nmol g food and drinking water containing sodium selenite at 0, 11.4, or 22.8 nmol·ml for 30 days before gestation and thereafter up to Day 1...

The aim of this trial was to determine whether the selenium status of suckling calves could be improved by supplementing their dams' diet with organic Se instead of sodium selenite. A herd of 103 Hereford cows, which were on grass paddocks all year round, was divided into two groups. Both groups had free access to a mineral supplement that contained 30 mg of Se/kg; for one group the source of t...

1. Selenium is an essential micronutrient for both animals and man. Deficiency syndromes such as growth impairment, muscular degeneration, cardiomyopathy, hepatic degeneration and reproduction disturbances in ruminants and non-ruminants as well as exudative diathesis and encephalomalacia in poultry have been well documented. In veterinary medicine there is a widespread prophylactic and therapeu...

Selenite and organoselenium compounds have been examined at supranutritional levels for their ability to influence the activity and mRNA levels of chemoprotective enzymes in the livers of selenium-sufficient mice and the changes compared to those elicited by oltipraz. Compounds investigated included novel selenocysteine prodrugs that have previously been evaluated for their ability to reduce th...

Selenium nanoparticles (SeNPs) with a bright red colour have aroused worldwide attention due to their unique properties in selenium supplementation because of low toxicity and favourable bioavailability. A simple method was developed for making nanolayer on the inner surface Polyvinyl chloride (PVC) silicone tube. The were produced by reaction sodium selenite ascorbic acid. Red amorphous been s...

Cataract, the opacification of eye lens, is the leading cause of blindness worldwide. At present, the only remedy is surgical removal of the cataractous lens and substitution with a lens made of synthetic polymers. However, besides significant costs of operation and possible complications, an artificial lens just does not have the overall optical qualities of a normal one. Hence it remains a si...

In the crystal structure of Na2SeO3·5H2O [disodium selen-ate(IV) penta-hydrate], two Se, two selenite O atoms and one water O atom are located on a mirror plane, and one water O atom is located on a twofold rotation axis. The coordination of one Na(+) cation is distorted trigonal bipyramidal, formed by three equatorial H2O ligands and two axial selenite O atoms. The other Na(+) cation has an oc...