BACKGROUND Vitamin D has a range of biological effects including antiproliferative functions that are mediated through its receptors, encoded by the VDR gene. OBJECTIVES We investigated polymorphisms within the VDR gene for association with solar keratosis (SK), a biomarker for skin cancer, and examined interactions with skin phenotype. METHODS Among participants of the community-based Namb...

To cite: Chakradeo K, Narsinghpura K, Ekladious A. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2016215316 DESCRIPTION An 87-year-old woman presented with severe iron deficiency anaemia (haemoglobin 57 g/L). She also described a recent increase in the number of pigmented skin lesions on her trunk, which had become mildly pruritic. Her history included a right h...

A 71-year-old man presented with numerous pruritic seborrheic keratoses, with an eruptive onset over the course of 3 months. At presentation, he was also found to have hypopigmented tumors diffusely scattered throughout his body that were found to be mycosis fungoides on histologic examination. A theory regarding the pathophysiology of the development of eruptive seborrheic keratoses in the pre...

Although it is well known that ultraviolet light exerts a potent carcinogenic effect upon the skin, it is not known whether this effect is exerted directly upon a chromosome or a gene, or whether it is exerted indirectly through the formation of a carcinogenic compound. Indirect evidence that ultraviolet light does not exert its carcinogenic effect through the formation of a chemical resembling...

OBJECTIVE To identify chromosomal copy numbers of frequent genetic aberrations within squamous cell carcinomas (SCCs) and solar keratoses (SKs), and provide further evidence to support or challenge current dogma concerning the relationship between these lesions. DESIGN Retrospective analysis of genetic aberrations in DNA from SK and SCC biopsy specimens by comparative genomic hybridization. ...

Although it is well known that ultraviolet light exerts a potent carcinogenic effect upon the skin, it is not known whether this effect is exerted directly upon a chromosome or a gene, or whether it is exerted indirectly through the formation of a carcinogenic compound. Indirect evidence that ultraviolet light does not exert its carcinogenic effect through the formation of a chemical resembling...

Erlotinib is an inhibitor of the tyrosine-kinase domain of the epidermal growth factor receptor-1 (EGFR). This drug is used to treat some solid cancers, particularly advanced non-small-cell lung carcinoma. Similar to other EGFR inhibitors, erlotinib is responsible for a series of skin adverse reactions, particularly acneiform lesions. We described the incidental effect of erlotinib on actinic k...

Precancerous lesions and skin cancer are infrequent in Asians, and have received little documentation in the literature. Brazil has the world’s largest contingent of Japanese immigrants and their descendants, and 70% live in the State of São Paulo. The prevalence of such skin lesions in Japanese-Brazilians is unknown. This study aimed to assess the prevalence of actinic keratoses and non-melano...

Topical treatment for actinic keratosis with 5% fluorouracil has a recurrence rate of 54% in 12 months of follow-up. This study analyzed thirteen actinic keratoses on the upper limbs through confocal microscopy, at the time of clinical diagnosis and after 4 weeks of treatment with fluorouracil. After the treatment was established and evidence of clinical cure was achieved, in two of the nine ac...