Type 1 diabetes is characterized by infiltration of pancreatic islets with immune cells, leading to insulin deficiency. Although infiltrating immune cells are traditionally considered to negatively impact β-cells by promoting their death, their contribution to proliferation is not fully understood. Here we report that islets exhibiting insulitis also manifested proliferation of β-cells that pos...

The nucleocytoplasmic transport processes are mediated by soluble transport factors constantly navigating between nuclear and cytoplasmic compartments. Our understanding about nuclear export of general 'nuclear import factors' that deliver the cargo to the nucleus is still fragmentary. Utilizing green fluorescent protein tagged glucocorticoid receptor (GR) and relA as our working model and with...

Various cytokines and soluble growth factors upon interaction with their membrane receptors are responsible for inducing cellular proliferation, differentiation, movement, and protection from anoikis (a planned suicide activated by normal cells in absence of attachment to neighboring cells or extracellular matrix (EMC)). Among those soluble factors a major position is exerted by hepatocyte grow...

in order to study the canopy temperature effect on protein and soluble sugar, oil percentage and yield of soybean in different planting dates, an experiment was conducted as factorial based on randomized complete block design with three replications in karaj and moghan areas during 2012-13. the studied treatments were included cultivar (‘williams’ and ‘l17’) and planting date (5th of may, 5th o...

in order to study the effects of foliar application of zn and k on yield and some physiological traits of spring safflower (carthamus tinctorius l.), cv. esfahan 14, under drought stress, a pot experiment was conducted in research greenhouse of yasouj university. experiment was a factorial based on completely randomized design with three replications. factors consisted of drought stress (s1- wi...

The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRR) and transduces downstream signaling to activate the host defense. Here we report that in addition to direct PAMP-PRR interactions, live Candida albicans cells can release soluble factors to actively potentiate interleukin-6 (IL-6) and IL-8 production induced in human mo...

When immune cells detect foreign molecules, they secrete soluble factors that attract other immune cells to the site of the infection. In this paper, I study numerical solutions to a model of this behavior proposed by Kepler. In this model the soluble factors are governed by a system of reaction-diffusion equations with sources that are centered on the cells. The motion of the model cells is a ...

in order to investigate the effect of phosphorus fertilizer and spraying fe chellat in micronutrients absorption rate, rate of proline and soluble carbohydrates in bread wheat and some of its ancestral species in dryland condition, a factorial experiment was conducted with three factors consist of: p fertilizer (in two levels), spraying fe chellat (in two levels) and different species of wheat ...

in order to study the effects of pgpr application methods on proline and soluble sugars content of yarrow (achillea millefolium l.) under drought stress conditionsan experiment was performed at islamic azad university, yadegar-e-imam khomeini (rah) shahre-rey branch. this experiment was carried out in a split plot arrangement with randomized complete block design in three replications. experime...