This paper describes the development of a method to calculate the overall "greenness" of a pharmaceutical process that uses multiple solvents. This calculation is made by taking into account various environmental parameters and determining an overall greenness index. Through this method a scientist or engineer can effectively determine alternative, "greener" solvents or processes based on the u...

Background and objectives: Essential oils are used for their flavors and fragrances and their medicinal properties in food, cosmetic, agriculture and pharmaceutical industries. This study was focused on the selection of the best solvent(s) which would increase water solubility of ketone and phenol classes of essential oils. Methods: The solubility of s...

By an initial solvent screening of 18 solvents, 14 pure good solvents were selected for the crystallization of tolbutamide. Solid generation by the solvent-change method was carried out using the pure good solvents. Crystals were generated in only 10 of the 14 solvents. Different crystal forms of tolbutamide were obtained. Crystals were subjected to evaluation tests such as differential scannin...

The selection of a solvent or solvent system and the ensuing polymer–solvent interactions are crucial factors affecting the preparation of fibers with multiple morphologies. A range of poly(methylmethacrylate) fibers were prepared by pressurised gyration using acetone, chloroform, N,N-dimethylformamide (DMF), ethyl acetate and dichloromethane as solvents. It was found that microscale fibers wit...

Solvents are widely recognized to be of great environmental concern. The reduction of their use is one of the most important aims of green chemistry. In addition to this, the appropriate selection of solvent for a process can greatly improve the sustainability of a chemical production process. There has also been extensive research into the application of so-called green solvents, such as ionic...

Secondary surface texture is of great significance to morphological variety and further expands the application areas of electrospun nanofibers. This paper presents the possibility of directly electrospinning grooved polystyrene (PS) fibers using both single and binary solvent systems. Solvents were classified as low boiling point solvent (LBPS): dichloromethane (DCM), acetone (ACE), and tetrah...

Background and objectives: Essential oils (volatiles) are aromatic oily liquids prepared from different parts of plants and demonstrate various therapeutic and cosmetic properties. The dissolution of essential oils are not desirable in water, therefore the aim of this research was evaluation and selection the best co-solvents for increasing their solubility and bio availability...