In the pharmaceutical industry, the conventional tablet manufacturing process, a batchbased process based on solid powder handling, presents challenges such as inhomogeneous blending between Active Pharmaceutical Ingredients (APIs) and excipients, low yield, and low production rate. These difficulties can be resolved by the realization of a continuous manufacturing process through co-processing...

The separation of myo-inositol phosphates by ion pair, reverse-phase high performance liquid chromatography has been investigated. The retention of the inositol phosphates is dependent on both the polarity of the hetaeron utilized and on the pH of the solvent. A method is presented which permits the isocratic separation of multiple forms of inositol phosphates including isomers of myo-inositol ...

We study helix-coil transitions in an all-atom model of polyalanine. Molecules of up to length 30 residues are investigated by multicanonical simulations. Results from two implicit solvent models are compared with each other and with that from simulations in gas phase. While the helix-coil transition is in all three models a true thermodynamic phase transition, we find that its strength is redu...

Being the newest member of the carbon materials family, graphene possesses many unique physical properties resulting is a wide range of applications. Recently, it was discovered that graphene oxide can effectively adsorb DNA, and at the same time, it can completely quench adsorbed fluorophores. These properties make it possible to prepare DNA-based optical sensors using graphene oxide. While pr...

Ionic liquids (ILs) have been suggested as potential "green" solvents to replace volatile organic solvents in reaction and separation processes due to their negligible vapor pressure. To develop ILs for these applications, it is important to gain a fundamental understanding of the factors that control the phase behavior of ionic liquids with other liquids. In this work, we continue our study of...

T h e formation of insoluble complexes between sulfated polysaccharides and certain plasma lipoproteins was independently described by several investigators in 1955 (1, 2, 3). These complexes are formed a t neutral pH and in the absence of organic solvents, and are readily dissociated by increasing ionic strength or by the addition of chelating agents which remove certain metal ions that appear...

Ionic liquids (ILs) are regarded as non-molecular solvents, as they are composed entirely of cations and anions. ILs possess several excellent unique properties (e.g., low volatility, high thermal stability, specific electrochemical characteristics, easy design, tunable viscosity, and miscibility with water or organic solvents). These properties make ILs attractive candidates for various analyt...

A headspace solid-phase microextraction method has been developed for the determination of 8 pesticides in vegetables and fruits by using gas chromatography with an electron capture detector. Two types of fibers (polyacrylate, 85 microm and polydimethylsiloxane, 100 microm) have been assayed and compared. The main factors: extraction and desorption parameters, ionic strength, and the effects of...

Following our previous work on the solvent-response of uncharged diblock copolymer brushes (D. Meng and Q. Wang, J. Chem. Phys. 130, 134904 (2009)), we have performed continuum self-consistent field calculations to study the response (i.e., changes of brush height and surface-layer composition) of diblock brushes with only one block charged to various external stimuli, including solvent selecti...