نتایج جستجو برای: somatic hypermutation
تعداد نتایج: 43405 فیلتر نتایج به سال:
Checkpoint signaling in the context of a functional DNA damage response is crucial for prevention oncogenic transformation cells. Our immune system, though, takes risk attenuated checkpoint responses during immunoglobulin diversification. B cells undergo continuous and error-prone repair their genes process somatic hypermutation. An accompanying attenuation via ATR–Chk1 axis believed to allow b...
Somatic hypermutation of Ig genes is probably dependent on transcription of the target gene via a mutator factor associated with the RNA polymerase (Storb, U., E.L. Klotz, J. Hackett, Jr., K. Kage, G. Bozek, and T.E. Martin. 1998. J. Exp. Med. 188:689-698). It is also probable that some form of DNA repair is involved in the mutation process. It was shown that the nucleotide excision repair prot...
Somatic hypermutation of immunoglobulin variable region genes occurs within germinal centres (GCs) and is the process responsible for affinity maturation of antibodies during an immune response. Previous studies have focused almost exclusively on the immune response to haptens, which may be unrepresentative of epitopes on protein antigens. In this study, we have exploited a model system that us...
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